Today is the seventh "5.30 Science and Technology Workers’ Day", and the China Association for Science and Technology officially announced the list of the third national innovation first prize. The research team of pharmacokinetics and drug conversion of China Pharmaceutical University, led by China Academy of Engineering and Professor Wang Guangji of China Pharmaceutical University, won the medal of "National Innovation First Prize".

　　In mid-May, the reporter visited Academician Wang Guangji and his team in Jiangsu Key Laboratory of Pharmacokinetics of China Pharmaceutical University. The first impression that Academician Wang Guangji gave reporters was that he spoke slowly, humbly and kindly. In the interview, the reporter found that Academician Wang Guangji still used a non-smart phone that could only make calls and send text messages more than a decade ago. "I hope to study science better and not be disturbed too much by the outside world." Academician Wang Guangji said.

　　Over the years, Academician Wang Guangji’s team has focused on the frontier of biomedicine, breaking through the "stuck neck" problems in the biomedical field, such as the discovery of many new drug targets, the research and development and transformation of innovative biopharmaceuticals for precision treatment, cell drugs and high-end preparations.

　　On the wall of the team lab, there is a saying that success comes from strict self-management and perseverance.

　　Research team of pharmacokinetics and drug conversion for precision treatment in China Pharmaceutical University

　　Devote oneself to pharmacokinetics

　　Strive to break the "black box effect" of traditional Chinese medicine

　　What is pharmacokinetics? Wang Guangji replied that pharmacokinetics mainly studies the absorption, distribution, metabolism and excretion of drugs by the human body. In the past, people took a certain medicine, but they probably didn’t know how the medicine affected the body and made us get better or recover, which was similar to a "black box". Pharmacokinetics can make this "black box" transparent and change the efficacy of drugs from qualitative to quantitative. After taking a pill, you can observe when and what concentration the drug is in the human body, when it has the greatest efficacy, and when the drug has no effect and needs to be supplemented. Therefore, it is essential to establish a high-level preclinical pharmacokinetic technology platform for the creation and research of new drugs.

　　Wang Guangji became attached to pharmacokinetics more than 40 years ago. In the 1980s, the pharmacokinetics of drugs in China just started, and its research involved complex mathematical problems, which fascinated the young Wang Guangji and prompted him to choose this research field and go abroad for further study.

　　In 1995, Xia Lin, then Vice President of China Pharmaceutical University, invited Wang Guangji to work in China. He declined the invitation of foreign tutors and decided to return to China to devote himself to the discipline construction and scientific research of pharmacokinetics in the motherland. In Wang Guangji’s mind, there has always been a firm belief that scientists are persistent in science, but more persistent in the feelings of home and country. No matter how high your personal achievements are, you can’t compare with the joy of seeing the vigorous development of pharmacy in your motherland.

　　Today, after years of hard work, Academician Wang Guangji’s team has overcome a number of "stuck neck" technologies, and the internationally advanced preclinical pharmacokinetic technology platform established by the team has become an important support system for innovative drug research and development in China; Take the lead in expanding the pharmacokinetics of traditional Chinese medicine from single component to multi-component research; From macroscopic plasma to microscopic cells, the detection problem of drug concentration in cells is solved technically, and a new mathematical model is established to help clinical precise treatment. "Through the cross-integration of disciplines, we can see the process of drug metabolism in cells and how to enter the nucleus through the cell wall and how to distribute it after entering the cell. In this way, it can better guide clinical combined medication and precise treatment. " Wang Guangji explained.

　　It is precisely because the drug metabolism has become considerable and sensible that Wang Guangji’s team has also solved the problem that traditional Chinese medicine has formed a "black box" in the human body for many years. "In view of the difficulties in the detection of complex components of traditional Chinese medicine, the identification of metabolic pathways and the analysis of material basis, we have established an international advanced longitudinal research system on pharmacokinetics of traditional Chinese medicine, which not only reveals the role of multi-target and overall regulation of traditional Chinese medicine, but also explains the major scientific problems of treating both the symptoms and root causes of traditional Chinese medicine and promotes the modernization of traditional Chinese medicine." Wang Guangji said.

　　Juli original technology research

　　Help China’s biomedicine to "lead"

　　Innovation is the core competitiveness of biomedical industry. In recent years, drug research and development is developing from small molecule drugs, targeted drugs and antibody drugs to cell drugs. China’s biomedical industry is striding from "running with" to "running with" and then to "leading".

　　"Finding brand-new targets and developing class 1 innovative drugs" is the key to "leading the way" and the most difficult "hard bone" in pharmaceutical field. "Doing basic research is the key. Only when we lay a good foundation and walk ahead can we find more targets and produce more’ China drugs’. " Wang Guangji told reporters.

　　Scientific research comes from clinical needs, and also to better solve the problems of clinical needs. In 2019, Sun Lingyun’s team of Nanjing Gulou Hospital won the second prize of national technological invention for "Research on key technological innovation and clinical application of allogeneic mesenchymal stem cells in the treatment of refractory lupus erythematosus". In order to benefit more patients, Professor Sun Lingyun, then vice president of Gulou Hospital, sought the collaboration of Academician Wang Guangji, hoping to turn this medical technology into stem cell medicine, making the treatment safer, more effective and more controllable in quality. After three years’ efforts, this stem cell product independently developed by China for the treatment of lupus nephritis has entered the II clinical stage.

　　Academician Wang Guangji is doing experiments with students.

　　"In the past, drugs were constantly metabolized after being injected into the body and could not be regenerated, but when living cells were injected into the body as drugs, they could proliferate in the human body and then go where they needed to go. Therefore, cell drugs will have unique effects in treating immune imbalance and tissue repair. " Wang Guangji told reporters, "If chemical drugs and traditional Chinese medicine are the first generation drugs and vaccine biotechnology drugs are the second generation drugs, then cell drugs belong to the third generation drugs." Wang Guangji explained, "This is a revolution in clinical medicine with broad prospects. For the biomedical industry, this is a brand new track, which is worthy of our innovation. "

　　From a medical technology to the research and development of stem cell products, based on a mature technical system. A few years ago, Wang Guangji’s team developed a research technology system on pharmacokinetics and drug-forming properties of living cell drugs to meet the great demand of rapid development and drug-forming transformation of cell drugs such as CAR-T and stem cells, which can reveal the relationship between the fate and efficacy of living cell drugs in vivo and help to formulate clinical precise treatment plans.

　　Inherit the essence, keep the integrity and innovate. Traditional Chinese medicine is a treasure of our country. How to make traditional Chinese medicine better modernized is a subject before many pharmaceutical experts. "Traditional Chinese medicine is difficult to be recognized by the international medical academic community because of the problems of clear efficacy and unclear material basis, which seriously restricts the modernization of traditional Chinese medicine and its entry into the international medical market." Wang Guangji said.

　　In view of the low oral utilization rate of most traditional Chinese medicines and the accumulation of a large number of traditional Chinese medicine components in the intestine, Wang Guangji’s team put forward the theory of "symbiotic metabolism of traditional Chinese medicine-flora-host", revealing that traditional Chinese medicine components can play a remote regulatory role through "heart axis" and "brain-intestine axis". "Based on this research model, we found inspiration from a medicinal material in Compendium of Materia Medica, extracted new compounds, and discovered a new drug ZH01 which can quickly relieve depression. At present, we have applied for a patent." Wang Guangji introduced.

　　Academician Wang Guangji

　　Both wisdom and ingenuity

　　The essence of scientific research lies in the treatment of diseases by drugs.

　　The medical way is helpful to the world, and the fine industry is rich. In Wang Guangji’s view, pharmacists should not only have the kindness of doctors, but also have wisdom, ingenuity and harmony-

　　Wisdom, emphasizing the ability to put forward innovative ideas and methods, as well as unique scientific insights, will eventually bring new understanding and breakthroughs to China’s pharmaceutical industry, and do useful scientific research that can solve clinical problems and land; Ingenuity requires Excellence in experimental design, data analysis and interpretation of results, pursuing excellent scientific research quality and pushing scientific research to a higher level. Wisdom and ingenuity complement each other and together constitute the core quality of outstanding scientific researchers. Harmony, that is, cooperation, should maintain a humble attitude, actively communicate and cooperate with others, and draw inspiration and inspiration from different angles and ways of thinking. The most important thing is to persist in loving science, keep the passion and pursuit of scientific research, drive yourself forward in the field of scientific research with wisdom and ingenuity, and make contributions to scientific progress and social development.

　　In the team of Academician Wang Guangji, there are leading talents such as academicians, Changjiang scholars and national Jie Qing, and more and more "post-90 s" and "post-00 s" have joined. In the eyes of students, Wang Guangji is a strict teacher and a kind teacher.

　　"The team pays attention to bringing the old with the new, which can not only help young people establish a good research direction in the early stage of their scientific research career, but also set an example for them in scientific research. We not only pay attention to the communication and cooperation within the team, but also encourage and support interdisciplinary scientific research cooperation and exchanges with other teams to provide more learning platforms and development opportunities for young people. " Wang Guangji said that scientific research must not be done behind closed doors. Don’t just work hard, you must learn to look up and ask for directions. Pharmacy itself is an interdisciplinary science that combines medicine, chemistry and biology, and teamwork has become the key to promote interdisciplinary research.

　　Research team of pharmacokinetics and drug conversion for precision treatment in China Pharmaceutical University

　　Pharmacy is a long-time-consuming, high-input and high-risk industry because it has its particularity because it undertakes the "weight of life". The research and development of a new drug often takes about 15 years and costs 2 billion dollars, and less than 10% of the products that finally enter the clinic can be approved for marketing. This means that pharmaceutical research must endure loneliness and setbacks and always pursue Excellence.

　　"I often tell my classmates that to learn, we must constantly improve our insight and concentration on problems. This requires extensive literature reading and lifelong learning mode, and at the same time pays attention to the cultivation of practice and experimental skills. Don’t be afraid of failure, find the right goal and keep going, even if the experiment fails 100 times, it is enough for the ultimate success! As long as you are willing to study hard and be willing to work hard, you will always solve the problem and have a bright future. "

　　This year, Academician Wang Guangji is just 70 years old. From 1977 to now, he devoted himself to the study of pharmacokinetics. At that time, the young scallion had arrived in seventy years of age, and his hair had turned white. But he didn’t change his mind.

　　At the end of the interview, Wang Guangji told the reporter about an experience when he was studying: "Pharmacokinetics often takes a long time to collect blood samples continuously, and the experiment is very tiring. When I was young at the University of Queensland in Australia, I stayed in the laboratory for 48 hours. When the school security guard saw a light in the window to check, he was surprised and asked, why are you still here? "

　　The simple words of security guard are still imprinted on Academician Wang Guangji’s mind. Why are you still here? "It is also the motto of our team-success comes from strict self-management and perseverance." Academician Wang Guangji said. Up to now, his daily working hours are still from 8: 00 am to 12: 00 pm, which is not inferior to the young people in the team. "Scientific research should be carried out and the results should be for the people. Only by truly solving problems at the new drug development terminal and getting safe and effective results in clinical patients is the ultimate meaning of scientific research. "

　　Xinhua Daily Meeting Point reporter Ye Zhen

　　Correspondent Jiang Chentu/Cui Jiayue

　 　 Ask more doctors to choose a new treatment.

Sheng Xiujie, Chief Physician of Gynecology, Third Affiliated Hospital of Guangzhou Medical University

　 　 Gynecological tumor:

　　It is best to prevent and treat early surgery, chemotherapy and radiotherapy, and it is "three axes"

　　Surgery, chemotherapy and radiotherapy are still the main treatment methods for gynecological tumors, and other treatment methods are only used as auxiliary supplementary treatment methods to improve the curative effect with surgery, radiotherapy and chemotherapy.

　　Sheng xiujie　

　　Chief Physician of Gynecology, Third Affiliated Hospital of Guangzhou Medical University

　　Gynecological tumors mainly include vulvar tumors, vaginal tumors, uterine tumors, ovarian tumors and tubal tumors, among which uterine and ovarian tumors are more common. Professor Sheng Xiujie, director of gynecology department of the Third Affiliated Hospital of Guangzhou Medical College, said that the infection of human papillomavirus (HPV) has a certain relationship with cervical cancer, but the causes of other gynecological tumors are not clear, which may be related to factors such as heredity, environment, infection and immunity.

　　At present, there are many treatments for tumors. There are surgery, chemotherapy, radiotherapy, biotherapy and immunotherapy. However, at present, surgery, chemotherapy and radiotherapy are still the main treatment methods for gynecological tumors, and other treatment methods are only used as auxiliary supplementary treatment methods to improve the curative effect with surgery, radiotherapy and chemotherapy.

　　Sheng Xiujie reminded that the best way to deal with gynecological tumors is early prevention and treatment. Through pelvic examination and various auxiliary examinations, you can basically judge whether you have gynecological tumors.

　　Sheng Xiujie also pointed out that cervical cancer is the only cancer that can be clearly identified and prevented. To prevent cervical cancer, it is very important to screen cervical intraepithelial lesions, and this kind of screening needs to follow three steps of screening process:

　　Step one: cytology +HPV detection

　　Cervical cytological examination is the most basic method for screening cervical lesions, commonly known as "cervical curettage", commonly called TCT, CCT or LCT, etc. A brush is used to brush cells on the cervix, and thin-layer smear and computer-aided detection are used to detect "bad" cells at an early stage.

　　HPV detection, similar to the process of cytological examination, also uses a brush to obtain samples such as cervical tissues and secretions to detect whether HPV is carried. It can be used alone or combined with cytological examination as a primary screening method for cervical lesions.

　　Step 2: colposcopy

　　Colposcopy is suitable for cytological examination when abnormal cells are found, and further colposcopy should be done to make a definite diagnosis. This examination uses a special camera lens to observe and evaluate the cervical lesions, and can make a fixed-point biopsy of suspicious tissues of the cervix under the instruction of the lens to improve the accuracy of finding lesions.

　　Step 3: Histopathological examination

　　Including cervical biopsy and cervical conization, is a reliable method to diagnose cervical lesions. General lesions can be biopsied at single or multiple points under the guidance of naked eyes or colposcopy. However, for the lesions whose boundaries can’t be seen by colposcopy, the lesions are deeper than the cervical canal, and the biopsy is high-grade lesions (HSIL), diagnostic cervical conization is needed to confirm the diagnosis.　

Wang Bailin, Director of General Surgery and Director of Hepatobiliary Surgery, Guangzhou Red Cross Hospital

　　Liver cancer:

　　Early diagnosis is difficult, and the curative effect is not good in the middle and late stage.

　　It is best for patients with liver cancer to choose specialized consultation and treatment in large hospitals; Don’t blindly believe the advertisements and propaganda of informal medical institutions, so as not to delay the illness and delay the treatment; Be careful when searching hospitals online, so as not to be fooled.

　　Wang Bailin　　

　　Director of General Surgery, Director of Hepatobiliary Surgery, Guangzhou Red Cross Hospital

　　Liver cancer is one of the most common malignant tumors in China. It is difficult to diagnose in the early stage, and the treatment effect in the middle and late stage is not ideal. It is easy to relapse and metastasize, and the mortality rate is relatively high. Wang Bailin, director of general surgery and director of hepatobiliary surgery in Guangzhou Red Cross Hospital, said that the number of patients with viral hepatitis such as hepatitis B and hepatitis C in China is very large, and the number of hepatitis B virus carriers alone is close to 100 million, while "hepatitis-cirrhosis-liver cancer" will be transformed in a certain proportion, which is the "trilogy" of liver cancer, so there are many patients with liver cancer in China. Many patients with liver cancer don’t have obvious early symptoms and signs, and they don’t go to see a doctor until they have typical symptoms and signs. Their liver cancer has developed to the middle and late stage, and they have lost the opportunity of radical surgery and the outcome is relatively poor.

　　The treatment of liver cancer is a comprehensive treatment based on surgery. Wang Bailin said that surgery is the best treatment method, and it can also be combined with interventional therapy, radiofrequency ablation therapy, cryotherapy and microwave therapy. In recent years, patients with advanced liver cancer can choose targeted drug therapy if economic conditions permit, but the overall effective rate is less than 20%; If you can find a liver donor, you can also have a liver transplant.

　　Wang Bailin suggested that patients with liver cancer had better choose specialized consultation and treatment in large hospitals; Don’t blindly believe the advertisements and propaganda of informal medical institutions, so as not to delay the illness and delay the treatment; Be careful when searching hospitals online, so as not to be fooled.

Luo Rongcheng Dean, Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University

　　Lymphoma:

　　Biochemotherapy is the first choice, and the toxic and side effects of new drugs are reduced.

　　Compared with most solid tumors, the therapeutic effect of lymphoma is relatively good, especially in the clinical application of immunotherapy. The overall 5-year survival rate of diffuse large B-type lymphoma is over 60%.

　　Luorongcheng　　

　　Dean of Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine

　　It is reported that lymphoma is one of the fastest growing malignant tumors in the world. Among them, the incidence of lymphoma in China is increasing at a rate of 5% per year, and there are about 84,000 new lymphoma patients and more than 47,000 deaths each year. Faced with such a severe situation, it is urgent to promote standardized and individualized treatment of lymphoma. Lymphoma is a malignant tumor originating from the lymphatic system, which is mainly divided into Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). Non-Hodgkin’s lymphoma is more common in China patients, accounting for more than 80% of lymphoma.

　　"In fact, compared with most solid tumors, the treatment effect of lymphoma is still relatively good, especially in the clinical application of immunotherapy. The overall 5-year survival rate of diffuse large B-type lymphoma is over 60%." Professor Luo Rongcheng, dean of the Hospital of Integrated Traditional Chinese and Western Medicine of Southern Medical University and director of the Cancer Center of Southern Medical University, said that this benefited from the development of biotherapy technology, which enabled lymphoma to continue to adhere to cellular immunotherapy within five years after remission, and patients could get better results.

　　For example, Luo Rongcheng once treated a 16-year-old young Wang. When Wang graduated from high school, he suddenly had a stomachache. When he was sent to hospital, he found that a 20 cm tumor in the pelvic cavity caused intestinal obstruction. After biopsy, he was diagnosed with advanced diffuse large B-cell lymphoma. Fortunately, after eight times of biological chemotherapy, his symptoms were completely relieved and he escaped. For the next four years, he continued to receive cellular immunotherapy and was followed up for seven years. He has finished his college studies and now he has joined the work.

　　According to reports, the treatment methods of lymphoma mainly include immunotherapy, chemotherapy, radiotherapy and hematopoietic stem cell transplantation. The classification of lymphoma by the World Health Organization clearly points out that each pathological type of lymphoma is an independent disease, and the treatment adopted is also different. The patient must decide the treatment strategy according to the condition after a comprehensive examination.

　　At present, most lymphoma patients still prefer chemotherapy. Some patients combined with immune targeted therapy can significantly improve the effective rate and improve the survival time. Surgery is not the main treatment, but in a few cases, it can be considered. A large number of clinical research data show that 50%~60% of patients with early lymphoma are expected to be cured by using immunotherapy represented by monoclonal antibody rituximab in initial treatment.

　　The toxic and side effects brought by traditional chemotherapy often worry many patients. Luo Rongcheng said that the emergence of new chemotherapy drugs has significantly reduced the toxic and side effects. In addition, common toxic and side effects have mitigation strategies, so patients don’t need to worry too much. However, it should be reminded that if patients have a fever during chemotherapy, they must go to the hospital for a follow-up visit and don’t take it lightly. At present, according to the latest molecular classification, lymphoma can be divided into more than 100 types, and different types of lymphoma have different therapeutic effects. In general, Hodgkin’s lymphoma accounts for 9%~10% of lymphoma, which is a group of malignant lymphoma with relatively good curative effect. Non-Hodgkin’s lymphoma accounts for about 90% of all lymphoma cases. The classification is complex and the prognosis depends on the situation.

Wang Shunqing Director, Department of Hematology, Guangzhou First People’s Hospital

　　Hematological neoplasms:

　　The overall survival rate can reach 95%, and regular doctors will not "guarantee"

　　"Today, the cure rate and survival rate of blood tumors have been greatly improved, and some types of leukemia are completely curable."

　　Wang shunqing　　

　　Director, Department of Hematology, Guangzhou First People’s Hospital

　　When it comes to blood tumors, many people’s understanding still stays in the impression of the Japanese drama "Blood Suspicion", equating leukemia with terminal illness. "Twenty years ago, it was true that many leukemia patients had only two to three years between diagnosis and death. But today, the cure rate and survival rate of blood tumors have been greatly improved, and some types of leukemia are completely curable. " Professor Wang Shunqing, director of the Department of Hematology, Guangzhou First People’s Hospital, said in an interview.

　　Wang Shunqing told reporters that leukemia is divided into many types, quite a few of which have good therapeutic effects, and some of which are more difficult and easy to relapse.

　　"Take the most common childhood acute lymphoblastic leukemia in recent years as an example. This kind of leukemia is divided into’ standard risk type’ and’ high risk type’, among which’ standard risk’ patients account for the majority. More than 85% of patients with’ standard risk’ can be cured if they adopt a standardized chemotherapy plan. "

　　In addition, the cure rate of adult acute promyelocytic leukemia can reach 80%~90% through chemotherapy and drug treatment. There is also chronic myeloid leukemia. "This kind of leukemia is treated like chronic diseases such as hypertension and diabetes because of the targeted drugs with very significant effects. As long as patients take drugs for life, their condition can be controlled. At present, this targeted drug has been produced in China, the cost is not too high, and medical insurance can be reimbursed. " Wang Shunqing said.

　　As for those leukemia that are more difficult to treat, Wang Shunqing believes that the treatment effect has also been significantly improved compared with the past. "These leukemias can usually be treated by bone marrow transplantation or hematopoietic stem cell transplantation. These two technologies are very mature at present. Moreover, with the development of technology, the problem of matching between doctors and their families, which used to be difficult, has now been well solved. " For example, there is now a haploid transplantation technology, even if the donor bone marrow or stem cells are not completely matched with the patient, transplantation can be performed.

　　"So, the overall survival rate of leukemia patients can reach more than 95%." Wang Shunqing said. However, the treatment effect and the survival rate of patients are definitely based on the standardized treatment plan.

　　In addition, more and more attention is paid to precise treatment of leukemia, and some types have reached the genetic level. "So some leukemias need to do more tests before starting treatment, in order to have accurate guidance on the treatment plan and predict the prognosis." Wang Shunqing said, but sometimes patients don’t understand. On the one hand, they feel that so many tests are too much for the economy, and on the other hand, some patients have misunderstandings or distrust of doctors. "Because in a regular hospital, it must be very objective for doctors and patients to talk about treatment, and doctors will never assure patients that’ how much you spend on this disease, we will definitely cure you’. On the contrary, it is precisely because of the uncertainty of medicine that many factors will affect the treatment process, so the doctor will tell the patient the risks and benefits in the treatment process completely, and then analyze with the patient which scheme is the most favorable. "

　　Combined with his many years of medical experience, Wang Shunqing suggested that the majority of patients, unfortunately diagnosed with tumors, should not despair at first, because with the development of medicine today, the treatment effect of many tumors is much better than before. Secondly, you must consult a specialist in a regular hospital, and don’t blindly believe in advertisements, remedies, etc., especially those "magic doctors" who clap their chests and say that they will definitely cure the tumor.

Wang Cunchuan, Vice President and Director of Gastrointestinal Surgery, First Affiliated Hospital of Jinan University

　　Gastrointestinal neoplasms:

　　Ask more doctors about the unrecognized new treatment.

　　Radical resection of gastrointestinal tumors should be considered first. Some new treatments, such as cell biotherapy, are still in the clinical experimental stage, and their efficacy has not been recognized. It is recommended to know more and ask more doctors before choosing.

　　Wang cunchuan　　

　　Vice President and Director of Gastrointestinal Surgery, First Affiliated Hospital of Jinan University

　　Gastrointestinal tumors are very common, such as colorectal tumors, and some of them can be prevented. Professor Wang Cunchuan, deputy dean of the First Affiliated Hospital of Jinan University and director of gastrointestinal surgery, said that 75% of colorectal tumors are gradually developed from polyps, which can be found and removed by colonoscopy, which is the best prevention. If you have gastrointestinal tumors, you should first consider radical resection, and now do more minimally invasive surgery, and then combine chemotherapy and radiotherapy.

　　Some new treatments, such as cell biotherapy, are still in the clinical experimental stage, and their efficacy has not been recognized. However, some privately contracted and profit-oriented medical institutions sometimes exaggerate their efficacy, which may delay patients’ illness and may cause economic losses. It is recommended to know more before choosing, such as asking more doctors.

　　Wang Cunchuan said that at present, public top three hospitals, especially the affiliated hospitals of universities, generally have a good diagnosis and treatment system, a perfect multidisciplinary consultation system and complete equipment. Their medical staff are often exposed to cutting-edge medical expertise and have more experience in the treatment of tumor diseases. If you do four-level surgery such as radical resection of gastrointestinal tumors, it is more secure to go to these hospitals. Some private specialized hospitals and community hospitals have different levels of supporting software and hardware, which is not a big problem in dealing with common diseases, but not necessarily for radical surgical treatment of tumors. Patients are advised to choose carefully and learn more about the qualifications of medical institutions and doctors. Searching for information about seeking medical advice on the Internet, he suggested logging on to the official website of public hospitals, and it is best to go directly to the hospital to see a doctor for on-site consultation, while websites with competitive ranking, commercial promotion or lack of certification are likely to cause information asymmetry, or confusion and misleading.

Director, Cancer Center, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Lin Lizhu

　　Treatment of tumor with combination of traditional Chinese and western medicine;

　　Eat Chinese medicine after seeing western medicine? It’s not that simple

　　After receiving the treatment of modern medicine, cancer patients should not blindly prescribe Chinese medicine by looking for "Chinese medicine practitioners" who do not know the source. They must use drugs in a dialectical way under the guidance of Chinese medicine practitioners with experience in oncology, combined with the needs of the course of disease.

　　Lin Lizhu　　

　　Director of Cancer Center of the First Affiliated Hospital of Guangzhou University of Chinese Medicine

　　What should relatives and friends do if they find out about cancer? What factors should be considered when choosing a treatment plan?

　　Professor Lin Lizhu, director of the Cancer Center of the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, said that there are many treatments for cancer. Taking the primary liver cancer with high incidence as an example, early surgical resection is the best treatment. If the patients in the middle and late stages are not suitable for surgery after diagnosis, they should consider intervention, radiotherapy and chemotherapy and even targeted drug treatment according to the specific situation. However, most patients with liver cancer have suffered from hepatitis B and cirrhosis. Whether it is surgery, radiotherapy and chemotherapy or targeted therapy, the treatment has its own limitations, and preventing recurrence is still a difficult problem that has to be considered. Therefore, multidisciplinary and standardized comprehensive treatment has become the consensus of the medical community.

　　"Our research found that Chinese medicine combined with modern medicine can play different roles for patients with various cancers at different stages." Lin Lizhu revealed that a 7-year-old collaboration group of state administration of traditional chinese medicine’s "Eleventh Five-Year Plan" key specialty liver cancer, led by the First Affiliated Hospital of Guangzhou University of Chinese Medicine, verified that the results of a multi-center retrospective cohort study in 15 hospitals in the United Nations showed that Chinese medicine played a synergistic and attenuated role in the minimally invasive treatment and systematic treatment of liver cancer. Some traditional Chinese medicines can affect the DNA synthesis of hepatocellular carcinoma cells and inhibit their proliferation. In addition, Chinese medicine combined with interventional therapy can reduce liver function damage, protect residual liver function, and even make some large liver cancer that cannot be intervened become interventional, thus improving the curative effect of liver cancer and the quality of life of patients and prolonging the survival period.

　　"But unfortunately, many people don’t understand the combination of Chinese and Western medicine, thinking that after reading western medicine, they can eat some Chinese medicine." Lin Lizhu said with emotion. There are still many cancer patients who regard Chinese medicine as the last treatment for cancer, and they only come to Chinese medicine when various means such as surgery, radiotherapy and chemotherapy are exhausted. This is a misunderstanding. She explained that Chinese medicine emphasizes the treatment based on syndrome differentiation and the concept of "holistic" treatment, which can complement and complement each other with modern medicine (western medicine) such as surgery, radiotherapy and chemotherapy for "local" lesions. Still taking the treatment of liver cancer as an example, the 5-year recurrence rate is still as high as 50% after surgical resection of the focus in early patients. Strengthening spleen and protecting liver with Chinese medicine immediately after operation can improve the immunity of patients, promote the recovery of viscera function and reduce the recurrence rate; For patients with liver cancer in the stage of radiotherapy and chemotherapy, combined with traditional Chinese medicine treatment can reduce the side effects of drugs, reduce the damage to patients’ liver function, and help improve their quality of life and survival.

　　"However, the treatment of tumors with integrated traditional Chinese and western medicine is also a highly professional subject, which requires doctors to understand the knowledge of standardized treatment of tumors in modern medicine and must also have experience in treating tumors in traditional Chinese medicine." Lin Lizhu reminded that after receiving the treatment of modern medicine, cancer patients should not blindly prescribe Chinese medicine from unknown "Chinese medicine practitioners", but must be guided by Chinese medicine practitioners with experience in oncology, combined with the course of the disease. (Reporter Huang Rongfang, Ren Shanshan, He Xuehua, Wu Junyi, Li Heng, Weng Shuxian, Wang He correspondent Li Shaobin, Jin Juan, Jian Wenyang, Fang Ning, Zhang Qiuxia, Cui Yanling, Zhang Cancheng, Huang Xianjun, Bai Tian)

With the rapid development of intelligent driving technology today, Equation Leopard 8 Intelligent Driving Edition has become an intelligent benchmark in the field of hard-core off-road SUVs with its Huawei Gankun Intelligent Driving ADS 3.0 system and a series of innovative "brain-controlled" black technologies. This model not only redefines the intelligent boundary of off-road vehicles, but also allows drivers to experience unprecedented technological charm.

Huawei ADS 3.0: end-to-end intelligent driving, opening a new era of the whole scene

The most striking thing about Leopard 8 Intelligent Driving Edition is its Huawei Gankun Intelligent Driving ADS 3.0 system. As the world’s first high-level intelligent driving system with end-to-end architecture, ADS 3.0 completely breaks the dependence of traditional intelligent driving systems on high-precision maps and realizes the whole scene from parking spaces to parking spaces. Whether it’s urban congested road sections, expressways or complex off-road scenes, ADS 3.0 can realize intelligent lane change, intelligent obstacle avoidance, intelligent speed regulation and other functions through laser radar and visual fusion sensing technology, making driving easier and safer.

In the parking scene, ADS 3.0 also showed great strength. ADS 3.0 can easily cope with parking in extremely narrow parking spaces, parking at the front of the car, parking at the rear of the car, and even parking without parking lines. What’s even more amazing about Songyuan Snacks is that its parking and driving function supports parking away from the car. The driver only needs to get off the bus, and the car can automatically complete the parking operation, which truly realizes the convenient experience of "getting off and leaving".

Yunnian -P hydraulic suspension: intelligent preview, off-road riding on the ground.

In addition to the powerful intelligent driving system, the Leopard 8 Intelligent Driving Edition is also equipped with the Yunqi -P intelligent hydraulic body control system of the same model as Looking Up at U8. This system integrates three core technologies: mechanical, hydraulic and electronic control. Huizhou Snacks has three major functions, including the maximum suspension stroke height of 140mm, three-level stiffness and intelligent damping, as well as two major capabilities: active preview and four-wheel linkage. In the off-road scene, Yunqi -P system can sense the road conditions in real time, automatically adjust the suspension height and stiffness, and ensure that the vehicle always maintains the best driving state.

What’s more worth mentioning is that the Leopard 8 version is also equipped with a "violence mode". This mode can accurately identify the ground slip rate and carry out adaptive control by carrying the road surface identification technology. Within 200 milliseconds, the power can be output to the wheel end, and the peak torque output time is less than 2 km/h, thus significantly improving the performance of the motor in low-speed off-road. Whether it’s a 100% 45-degree forward climb or a 70% 35-degree reverse climb, Leopard 8 Zhijia Edition can easily cope with it, even on the complex terrain such as Sanlianpo and Shalingtou in online celebrity.

Lingyuan Vehicle-mounted UAV: Aerial perspective, unlocking new off-road gameplay.

Leopard-8 Intelligent Driving Edition is also equipped with the "Lingyuan Vehicle-mounted UAV System" jointly built with DJI. The roof comes with a smart apron, and the drone can take off and land dynamically, automatically follow the shot, and generate a travel blockbuster with one click. Whether it’s a family trip to record the scenery or a professional off-road survey of the terrain, the car can be transformed into an "aerial photographer" and unlock the nine scenes. Through the car system, drivers can also view the pictures taken by drones in real time and plan the best off-road route, making off-road travel more intelligent and interesting.

Intelligent cockpit: AI empowerment to create a top driving experience

In terms of smart cockpit, Leopard 8 Smart Driving Edition also spares no effort. The new car adopts BYD 9000 chip with 4nm advanced process, which integrates the intelligent voice and intelligent image of AI model, providing drivers with a smooth and intelligent interactive experience. Through the "Fanghua" handcart interconnection function, drivers can also extend the applications and services on Huawei mobile phones to Qingyang escort in the car, realizing information sharing and interoperability. In addition, the Leopard 8 Smart Driving Edition is also equipped with luxury configurations such as 128-color ambient lights and 18-speaker Divare audio, which makes the driving experience more comfortable and enjoyable.

Safety performance: all-round protection, guarding every trip.

In terms of safety performance, Leopard 8 Smart Driving Edition also performed well. Its non-loaded body +CTC battery integrated design, the impact resistance is 10 times higher than the industry standard. The 14 airbags and infrared night vision system of the whole vehicle cover 300 meters of detection, and with Huawei’s omni-directional anti-collision technology, risks can be predicted in advance in rainy and foggy days. Whether in urban roads or off-road scenes, Leopard 8 Smart Driving Edition can provide all-round safety protection for drivers and passengers.

Special feature of 1905 film network "I have been an actor for more than 30 years, and I will look back for ten years. With the development of the country and society, I have experienced magnificent historical changes in the 21st century. From the 40 s to the 50 s, this is the most glorious decade for an actor. I don’t think it has been white. "

In recent years, he has successively appeared in films and other works. He said that if you can bring a touch and gain to the audience through your role, that is the best response.

"Keeping the island is keeping the country, and keeping the country is keeping the home." Zhang Hua, who "read" The Islander, was particularly impressed by this line. Looking at the moment when the "island keeper" guards the national flag every day, she suddenly feels a warm current in her heart. With the ups and downs of the plot in the play, she cried and laughed, laughing and crying.

Zhang Hua is a special blind movie fan. Since he was blind for more than ten years, he has been supporting his life by movies. She is one of the most active audiences in the cinema for the blind. Whether it is a new film or an old one, it is her "good heart." In her view, the film is a tool for her to communicate with the outside world, and it is also a gift to accompany her through the rest of her life.

Movies, sharing a better life. The film channel specially launched a series of documentary reports on "This Decade, Our Film Life". In this programme, we will talk to actor Hou Yong and visually impaired Zhang Hua, and feel their pursuit and love for the art of light and shadow.

Actor Hou Yong: I haven’t lived in vain for ten years.

Unlike many peers who love movies and become actors, Hou Yong was an actor first, and then fell in love with movies.

He was originally a drama actor. His first contact with the film was in 1988. As an extra actor, he was responsible for yangko dancing in Red and White. "Maybe my body language expression ability is slightly stronger. I was arranged to stand in front, and there were hundreds of people behind me." Hou Yong still remembers that it was a big scene, unlike multiple camera now, when there was a camera, and they were very excited when they saw the camera.

Because of this experience, he was always in awe of the camera, so that later, no matter whether he played a small role or a leading role, as long as he stood in front of the camera, he felt extremely lofty and sacred.

Having served in the army for 27 years, Hou Yong is often invited to create some positive roles.

Henry Hui Wang, a special soldier in "General Chen Geng", Chen Geng, a patriotic warrior in "General", Tang Shaoyi, a political activist in "Heroes of Fire", Wu Chenguang, the commander in chief, and Wang Changjie, the minister of the People’s Armed Forces in "The Islander" … Through light and shadow, he left a lot of roles that were deeply rooted in the hearts of the audience.

The Islander pushed Hou Yong’s acting career to a new peak. With the role of "Wang Changjie" in the film, Hou Yong was awarded the Best Supporting Actor in the 36th Popular Film Hundred Flowers Award.

The film is based on the story of Wang Jicai, former director of Kaishan Island militia post in Guanyun County, Jiangsu Province, and his wife Wang Shihua. Hou Yong revealed that he was the only one in the whole cast who had really seen Wang Jicai.

He and Wang Jicai are both from Jiangsu. One year, Lianyungang moral model presented an award, and he was lucky enough to know this moral model as an awarding guest. Unfortunately, not every few years, Wang Jicai died from overwork. Later, the script of Island Keeper was handed to Hou Yong, who accepted it without hesitation.

"Chang-jie wang and Jude Wong have deep brotherhood. He not only has the guilt of "fooling" Wang Jicai to the island, but also feels very practical because of Wang Jicai’s persistence on the island. This is a very complicated role. " In Hou Yong’s view, "Wang Changjie" is not the protagonist, but assists the protagonist to complete the role orientation of drama expression, and has been conveying the belief of feelings for home and country to Wang Jicai. "It is a little difficult to play". In the role-building, he emphasizes to render and express the emotion between them through lines, dialogues, modeling and lens.

He was able to win another award for "The Islander", and he bluntly said that this is a gratifying thing. "Most of the award-winning actors are lucky, but the premise of being lucky is that they must work hard. The result of hard work may be recognized, and it may be submerged. I have been fortunate enough to have had several times and I feel very gratified. "

In recent years, the film and television industry in China has developed rapidly. Styles and themes are more diverse, and a hundred flowers blossom. Hou Yong said frankly that this is a very good era, and literary and artistic works are powerful. In order to adapt to the development of the times, while deeply cultivating the performances of positive characters, he also devoted himself to trying different types of roles and striving to "jump out of the comfort zone".

"I feel a sense of honor to be called out by the audience."

Hou Yong is particularly concerned about the audience’s evaluation of his role. He hopes that his role can bring some positive effects to others. A few days ago, at a friend’s party, a demobilized soldier sighed to him, "Mr. Hou, it was when I saw your movie that I was inspired to become a soldier." I have watched your movie many times in XinBingLian. "

At that moment, Hou Yong was particularly moved, moved his film career, and could influence the audience more or less.

Hou Yong is 55 years old. He always tells himself that every time he shoots a play, he shoots one less. What he always insists on is to perform every scene well and shoot every work well. I hope that no matter whether it is three or five years or even ten years later, I will be worthy of my heart and myself.

Zhang Hua, a blind movie fan: I love movies and will never change in my life.

"We always say that the eyes are the windows of the soul. Movies are the eyes in my life and the only way for me to talk to the world."

In 2007, Zhang Hua, who had been nearsighted for a long time, suddenly went completely blind. At that time, she was 52 years old and cried for several days because her eyes were broken. She felt that there was no hope in life and once had the idea of giving up. It was not until a friend introduced her that she began to get in touch with movies, and she regained her thoughts of life.

After blindness, Zhang Hua has always been a loyal audience of the cinema. It is reported that the Mind Cinema is specially designed for the visually impaired, and volunteers will provide them with professional film explanations. The cinema has moved from place to place several times, but no matter whether it can only sit in the small courtyard at first or sit comfortably on the sofa chair now, as long as it is not sick and hospitalized, Zhang Hua will appear in the cinema on time every week, sit in the front row and concentrate on "watching movies".

Over the years, she has seen "The Islander" and remembered the model mind that "defending the island is defending the country, and defending the country is defending the home". She has seen it, and she is really moved by the volunteers who fought bravely in the ice and snow to resist US aggression and aid Korea.

Zhang Hua said with a smile that when she was young, her eyes were good, but she didn’t have time to watch movies. Now that I can’t see, I find that I haven’t seen many movies. She will spend the rest of her life making up all the good movies she has left behind.

"The glory of the golden hall may be the dream of countless Cai-ling wang. It was a dream like a bubble that made him brave to face everything … "

"A man appeared on the screen. He looked at the distance with a telescope in the storm. He was Wang Jicai, the island keeper. In the sun, the figure of the island keeper disappeared, and his wife cried … "

Although invisible to the eyes, Zhang Hua can still imagine vivid pictures and wonderful plots under the vivid interpretation of volunteers. During these days of blindness, she can’t see the mountains and rivers with her own eyes again, but movies are like her eyes, which bring her to feel the prosperity of the world and the brilliance of human nature.

In many excellent movies, she not only got a pleasant viewing experience, but also gained a belief that supports her life. For example, the hero models in some plays are also blind, but they still stubbornly live and never give up easily. This also makes Zhang Hua understand that there is always hope in life.

For more than ten years, movies have almost become the only source of Zhang Hua’s spiritual life, entertainment life and communication with the outside world. In her words, the film broadened her horizons, increased her knowledge and changed her life.

Today, the film industry in China has developed for a hundred years. In the twilight of her life, she was lucky enough to witness China’s films making great achievements. Zhang Hua felt that the more good films she watched, the faster she watched movies in the second half of her life might not catch up with the development of China’s films. But anyway, "I love movies, and I won’t change in my life …"

　　In June, many print shops in universities began to get busy. Papers are printed and bound from here, and the eyes of college students around the machine are full of expectation, comfort and a little relief. Those who can walk into the print shop are the "winners in life" in this graduation thesis season, because they have finally reached the final step of graduation thesis completion.

　　In the dormitory next to the printing shop and in the library not far away, many students are still revising their papers over and over again. The hot topic "How strict is the duplicate checking of papers" in Weibo, which has a reading volume of 150 million, is all their voices. Last year, after the university entered the "strict era", the auditing standards for graduation thesis in colleges and universities have improved a lot. Therefore, this essay season is much more difficult for many college students than in previous years.

　　Strict word is the first word, and the paper "paddling" has become a past tense.

　　"Are you sleeping? But I can’t sleep while I’m writing a paper. " Many students sigh in the circle of friends late at night.

　　Qu Weiwei, a master graduate from a university in Hunan Province, found that this year’s graduation season was more difficult than last year.

　　"The school obviously has much higher requirements for graduate students than last year. Our paper duplicate checking standard is 20%. Even if the paper didn’t meet the duplicate checking standard before, it can be changed to more than 30% ‘ Paddle ’ Passed, but now it is stuck 20%. " Qu Weiwei said.

　　As early as last September, the Ministry of Education issued the Notice on Paying Close Attention to the Implementation of the Spirit of the National Conference on Undergraduate Education in Colleges and Universities in the New Era, emphasizing that colleges and universities should comprehensively sort out the teaching contents of various courses, eliminate "water courses", create "gold courses", strictly control the exit of graduation, and resolutely cancel the "clear examination" system.

　　In October of the same year, the Opinions on Speeding up the Construction of High-level Undergraduate Education and Comprehensively Improving Talents Training Ability (hereinafter referred to as "40 Articles on Higher Education in the New Era") issued by the Ministry of Education clearly stated that the whole process management of graduation design (thesis) topics selection, topic opening and defense should be strengthened, and the form, content and difficulty should be strictly monitored to improve the quality of graduation design (thesis). Strengthening the management of undergraduate graduation project (thesis) is a measure to pay close attention to undergraduate education and teaching.

　　This year’s graduation season, many colleges and universities have strengthened their management on "strict out". In April, Tsinghua University released the latest revised "Detailed Rules for the Implementation of the Administrative Provisions on Disciplinary Actions of Students in Tsinghua University", in which the remarkable change is that the punishment for academic misconduct has been increased, and the plagiarism of dissertations can be expelled from school. The original punishment was to give "the above punishment."

　　On May 6th, the Academic Affairs Office of Emei Campus of Southwest Jiaotong University issued the Notice on Doing a Good Job in Checking the Duplicate of Graduation Design (Thesis) in 2019, which shows that the duplicate checking of graduation design (Thesis) will increase the comparison database of college students’ theses (including this one). If students from the same department and school are found to plagiarize from each other, the Academic Affairs Office will start the investigation procedure, and the situation will be dealt with strictly.

　　In addition, the school also requires teachers and students to sign a "commitment letter", promising that they have studied the Measures for Dealing with False Dissertations by the Ministry of Education, the Notice of the General Office of the Ministry of Education on Strictly Investigating the Sale and Writing of Dissertations in Colleges and Universities, etc., and strictly implement the requirements of the Ministry of Education and the school on the management of graduates’ student status, curriculum assessment and graduation design (thesis) documents.

　　"In the past, because of the wide policy, we can use Taobao, which is not accurate but affordable, to check the weight, but now it is required to be based on HowNet, and each check needs more than 200 yuan." Qu Weiwei said.

　　Behind the word "Yan", the pain in the essay season is usually "lack of cultivation"

　　For many college students, the "difficulty" of the thesis season is the whole process, from the topic selection to the thesis defense.

　　In the view of Wang Xudong, a senior student in the School of Computer Science, Huazhong University of Science and Technology, writing the paper itself is not the most difficult, but the experimental part in the paper. He said that at the beginning of his graduation project, the topic selection and opening defense were relatively simple, but he was still secretly "glad" when he encountered a series of troubles.

　　"Because of a small formula error, hundreds of calculation results were all invalid, and a week’s efforts fell short. Every time I finally made new progress, I took it to discuss with my teachers and seniors, and then I found myself making many low-level mistakes, so I had no choice but to start all over again. In addition, because my graduation project is a theoretical research, I can’t prove the theoretical results through rigorous experiments with my current ability. This is also a problem I have encountered, that is, there is no strong practice to support the theoretical conclusions. "

　　Yu Zhenyuan, a senior graduate of Xi ‘an Jiaotong University, said that the graduation process was "extremely difficult". "I need to use a more complicated test-bed for my graduation experiment, but any link of this test-bed will go wrong. We have to fix it from beginning to end. In the experiment, what I don’t know accounts for the majority, and what I can really understand accounts for the minority. My data are very strange. "

　　In addition to the hardware itself, accurate chemical experiments also have high requirements for personal operation. On the morning of the interview with China Youth Daily and Zhongqing Online reporter, Yu Zhenyuan broke the instrument due to operational errors, which made him very upset.

　　Regarding the "pain" of college students in the graduation thesis season, Xu Fei, president of Southwest Jiaotong University, said in an exclusive interview with China Youth Daily and Zhongqing Online reporter that "students have problems in knowledge, ability and expression, and graduation thesis writing makes these problems gather together, which leads to the misery of students."

　　Xu Fei believes that the quality of college students’ graduation thesis is not high at this stage, which is mainly reflected in the lack of solid knowledge, the lack of depth and comprehensive ability of students to master theory, and the poor ability of independent thinking, investigation and research, problem solving and analysis, which leads to the lack of novelty, depth and innovation in the research topic of graduation thesis.

　　"If a student usually does well, he should not feel very painful when writing a paper. Instead, the paper should be a stage for him to show himself." Xu Fei said.

　　What abilities can solve the problem of "paper difficulty"

　　In recent years, many experts and college teachers have said that the poor quality of college students’ graduation thesis is mainly due to their lack of study and training in scientific writing, which leads them to write their graduation thesis for the first time in their lives. Students don’t know where to start, instructors are miserable, and the quality of papers is often not high.

　　In this regard, Xu Fei believes that it is necessary to improve students’ scientific writing level, and senior undergraduate students should set up relevant elective courses to teach students how to conduct scientific research and academic writing, or give guidance to students on how to write graduation thesis through academic lectures.

　　Last year, Qiu Yong, president of Tsinghua University, announced the opening of "Writing and Communication" course for freshmen in 2018, which is expected to cover all undergraduates by 2020, and strive to provide courses and guidance for graduate students. This has aroused widespread concern in society. At the end of May, Tsinghua University Writing and Communication Teaching Center issued a notice for recruiting teachers, and recruited 10 more teachers for outstanding scholars, postdoctoral students and fresh doctoral students at home and abroad.

　　It is reported that the course adopts two parallel modes: one credit and two credits. What each class teaches together is mainly the paradigm of reasoning writing and how to modify and perfect an article. More specifically, it mainly includes choosing the topic, sorting out the ideas of the article, establishing the logical structure, checking and modifying the grammatical errors, elegant expression, etc., but the topic is chosen by the students themselves. It is not mandatory to use uniform teaching materials in the course, but the consistency of training requirements in the whole process is important.

　　Peng Gang, a professor in the history department of Tsinghua University and director of the Academic Affairs Office, once said that writing training should first be thinking training. "It is very important for students to find a problem and think from different angles. If you want to write, you must first learn to think, and learn to think methodically and hierarchically. This is also the highest standard I expect: the writing course not only exercises students’ writing ability, but also enables students to ‘ Open your eyes ’ General course ".

　　As for the students’ "miserable" in the graduation thesis season, Xu Fei thinks that there are several reasons besides the lack of writing ability.

　　From the students’ point of view, they usually have a lot of knowledge, but they are not solid enough to learn, and there is a phenomenon of superficial and superficial. Students rely too much on search engines in their daily study, and there are deficiencies in memory and independent thinking. "Everything is at your fingertips, and everything has an answer. Students will feel ‘ Why am I still studying ’ This is a big misunderstanding. "

　　On the other hand, students’ knowledge is fragmented, not structured, organized and systematic, and they have not incorporated other people’s knowledge into their own knowledge system. This leads to students being "dumbfounded" when they finally need organized text presentation.

　　Moreover, "many schools are short of teachers, and teachers put more energy into scientific research. In terms of teaching, the energy put on undergraduates is different from that put on master students and doctoral students. Undergraduates are the group with the least energy input from teachers, which is also an important reason for the difficulty in writing students’ papers. "

　　Xu Fei believes that although from the perspective of academic degree regulations, undergraduates are not like master students and doctoral students, they have to submit papers to obtain their degrees, but it is necessary to adhere to the practice of requiring undergraduates to submit graduation papers. "Graduation thesis can comprehensively show and test students’ mastery of what they have learned and their ability to solve practical problems by using what they have learned. It is more important for undergraduates to write graduation thesis, from topic selection to data collection, to paper organization, writing, revision and final drafting, which is the most basic process of academic research and academic training".

　　"Graduation thesis is the last big homework for students." Xu Fei said.

　　(At the request of the interviewee, Qu Weiwei and Yu Zhenyuan are both pseudonyms.)

　　China Youth Daily Zhongqing Online Reporter Sara Ye Intern Ye Wei

　　CCTV News:On the afternoon of December 13th, the State Council Joint Prevention and Control Mechanism held a press conference to introduce the health management of key population.

　　A reporter asked, some elderly people who live alone think that they have less contact with society and there is no need for vaccination. What do you think of this phenomenon? Do elderly people living alone need vaccination?

　　Wang Huaqing, chief expert of immunization program of China CDC, said that living alone does not mean being completely isolated from society. At the early stage of COVID-19 epidemic, because the source of infection was not extensive, the risk of infection was relatively low for most people. However, we know that the virus is very contagious, spreading very fast, and the spreading process is hidden. In addition, COVID-19 has been spreading continuously in some areas. In this case, the risk of infection is increasing for anyone, including the elderly who live alone.

　　Wang Huaqing said, why are the elderly at high risk of serious illness and death? There are two reasons: first, his immunity is declining with his age. Second, because most elderly people have basic diseases, experts have also said that after being infected with COVID-19, it will also lead to the risk of aggravation of basic diseases. In this case, we suggest that the elderly should be vaccinated as soon as possible, including full vaccination and enhanced immunization, which can provide better protection for the elderly and give their families peace of mind.

　　[Global Times correspondent in the United States Ying Chen Global Times reporter Zhao Juekun Ren Zhong] "We will invest in the United States. We will succeed in America. We will win the economic competition in the 21st century in the United States. " After US President Biden finally signed the Chip and Science Act of 2022 into law on August 9, local time, he released this ambitious tweet. While providing huge subsidies to chip manufacturers in the United States, the bill requires these companies to agree not to develop the manufacturing of precision chips in China. It is no wonder that "Nihon Keizai Shimbun" called the promulgation of this bill the warming of the US "science and technology arms race against China". China’s Foreign Ministry spokesperson Wang Wenbin rebuked the so-called "protective measures" in the law on the 10th, showing a strong geopolitical color and "another example of the United States engaging in economic coercion". Although Washington’s China hawks tried to use this bill to strike a "precise blow" to China’s chip industry, few international mainstream media predicted that the United States could win this selfish and arrogant chip war. On the 9th, the British Broadcasting Corporation (BBC) quoted Jin Keyu, a professor at the London School of Economics and Political Science, as saying that he was worried: "I imagine a world divided into two parts, half of which uses China’s information systems and infrastructure, and the other half uses American information systems and infrastructure.Obviously, there will be a huge loss of efficiency. "

　　If you want subsidies, you must "exclude China"

　　"More than 30 years ago, the United States owned 40% of the global production of chips. Since then, our economic pillar, the American manufacturing industry, has been hollowed out, and we have made chip manufacturing go overseas. " Biden said in a speech when signing the Chip and Science Act on the 9th, "Now, this law has brought the chip back to the United States."

　　Biden explicitly mentioned China many times in his speech at the bill signing ceremony. He said, "It is not surprising that the Communist Party of China (CPC) actively lobbied American companies to oppose this bill" and said that the United States "must lead the world in chip production". According to a BBC9 report on the 9th, the current supply of chips in the United States has dropped from 40% of the global supply in 1990 to only 10% of the global share.

　　The Nikkei Asian Review said on the 10th that the passage of the "boldest industry legislation in decades" in the United States marked a rare bipartisan cooperation in Washington. The New York Times commented that the Republican Party, which has always opposed the government’s high degree of intervention in business, now supports the Democratic Party bill, in addition to supporting the domestic chip industry in the United States, "to contain the chip industry in China".

　　According to the Wall Street Journal reported on the 10th, the bill is more than 1,000 pages long. The key content of the bill is to allocate 52.7 billion US dollars for domestic manufacturing of chips, including 39 billion US dollars for incentive plans and 11 billion US dollars for R&D and labor development plans. In addition, the government will provide 25% investment tax incentives for chip factories in the United States, with an estimated cost of $24 billion. There are about 200 billion dollars for scientific research.

　　Qatar Al Jazeera reported on the 9th that the bill also includes "important restrictions" demanded by Republicans and China hawks, that is, enterprises applying for federal subsidies must promise not to develop precision chip manufacturing in Chinese mainland. The bill stipulates that subsidized companies are prohibited from significantly increasing production of "advanced process" chips (generally referred to as chips below 28 nanometers) in China for a period of 10 years. Companies that violate the ban may be required to refund all subsidies.

　　On August 9, Micron, a chip maker, announced that it would seek the federal subsidy. Micron said it plans to invest $40 billion to build a new chip manufacturing plant in the United States by 2030. This investment will increase the share of the United States in the global memory chip manufacturing industry from the current 2% to 10%. Chip giant Intel also said it would apply for subsidies to support its plan to build two chip factories in Ohio. The company will also seek subsidies for its chip factory expansion plan in Arizona and its chip packaging factory in New Mexico. TSMC, the world’s largest chip maker, also said it would seek subsidies for building a chip factory in Phoenix.

　　Forcibly change the global pattern of chip industry

　　Li Zheng, an associate researcher at the American Institute of China Institute of Contemporary International Relations, told the Global Times reporter that the signing of this bill has provided the United States with more chips for international cooperation and negotiation, and the United States may accelerate the construction of the so-called "four-party alliance of chips", with industrial subsidies and market access as chips to win over South Korea, Japan and Taiwan, China, and form the "backyard" of the American chip industry.

　　On the 9th, BBC9 reported that the exclusive policy of the bill against China’s chip industry made many chip companies face the problem of "taking sides" between China and the United States. Because Chinese mainland is the largest chip market in the world, this "taking sides" approach makes TSMC, Samsung, Intel and other enterprises fall into a dilemma. Samsung has a memory chip manufacturing factory in Xi ‘an, SK Haishili has memory chip manufacturing factories in Wuxi and Dalian, Intel and Micron also have chip packaging and testing factories in China, and TSMC is the only company that produces advanced process chips below 28 nm in Chinese mainland (its Nanjing factory produces 16 nm chips). "This is directly targeted in the Chip and Science Act". The BBC reported that in fact, in the past, all American equipment manufacturers have received letters from the US Department of Commerce, informing them not to supply China with equipment for the manufacture of chips of 14 nanometers or less.

　　Security officials in Taiwan Province are forcing Foxconn to abandon its $800 million investment in Chinese mainland’s chip company Ziguang Group, the Financial Times reported on the 10th. Foxconn announced the investment last month, but an unnamed security official of the Democratic Progressive Party authorities claimed: "This will definitely not pass."

　　An unnamed industry insider said in an interview with Global Times that in recent years, the United States has taken various measures to create a "small circle" of chips that crowd out Chinese mainland, and the so-called "China guardrail" clause in this chip bill is seriously harmful to China and even the whole industry. In the future, the United States may rely on this dominant behavior of occupying the industrial chain to "make whatever countries produce", which may break the division of labor and pattern of the global chip industry.

　　China’s embassy in the United States said on the 9th that it "resolutely opposes" the bill, denouncing it as "cold war and zero-sum game thinking". The China Council for the Promotion of International Trade and the China International Chamber of Commerce also issued a document expressing their opposition on the 10th, arguing that the provisions in the bill discriminate against some foreign enterprises, highlighting that the United States and Italy intend to use government forces to forcibly change the international division of labor pattern of the chip industry, which has harmed the interests of enterprises from all over the world, including Chinese and American enterprises. "This is the ultimate arms race in the 21st century." The New York Times said on the 10th that "commercial and geopolitical motives" urged China to make chips as quickly as possible, while the United States had "competitive motives" to prevent China from acquiring advanced technology.

　　"It’s just copying China’s plays."

　　The New York Times said that shortly before the US bill came into effect, China’s chip manufacturers had just achieved a major technological breakthrough and announced that they had successfully manufactured 7-nanometer chips, "which surprised the world". NPR said on the 9th that the bill "may not be able to curb China’s influence", and it may force China to "make more independent innovations in chip manufacturing to catch up with the United States and its East Asian counterparts".

　　Republican lawmakers in the United States who disapprove of the bill say that this may just give more benefits to enterprises with high profits. "I know that Democrats want to say that this is a competitive bill, but it is just copying China’s script." Rep. Rogers, a Republican, said that in 2015, the China administration put forward the "Made in China 2025" action plan to invest or subsidize ten high-tech industries that China considered to have long-term strategic value, and now the Biden administration is only trying to "spend more than China". According to the Nikkei Asia Review, China has invested US$ 150 billion in the chip industry, and TSMC said it plans to invest US$ 100 billion to expand its manufacturing capacity within three years. The European Union is also legislating for its own chip manufacturing. Therefore, the Chip and Science Act may not bring about "earth-shaking changes".

　　"None of the well-known American multinational companies, including Intel, grew up with government subsidies." Taiwan Province Zhongshi News Network said on the 10th. According to the estimation of Boston Consulting Group, if Washington adopts the policy of "hard decoupling technology" from China, it may even harm the interests of some American chip companies, or make them lose 18% of the global market share and 37% of the revenue, and reduce 15,000 to 40,000 high-skilled jobs. In other words, the subsidies provided by the Chip and Science Act may not make up for the cost of chip companies moving their factories from China to the United States.

　　Zhang Zhongmou, the founder of TSMC, said that the cost of producing the same chip in the United States is "about 50% higher than that in Taiwan Province". He said that it is "futile, wasteful and very expensive" for the United States to increase the local chip manufacturing industry. Collier, a risk management expert at Redford University in Virginia, told CNN on the 9th that no matter how hard countries try to support their manufacturing bases, it is impossible to decouple from the global supply chain, especially the design, manufacturing and raw materials of chips are distributed in many different countries and regions. "This is a huge network. No matter how hard countries try to localize manufacturing, a certain degree of interdependence is inevitable. "

　　In the interview, I said that I think I am quite stupid.

　　Four days after the release, Li Yang wrote a letter of apology to fans and sincerely said "I’m sorry to disappoint you".

　　Li Yang is writing an apology letter to the fans.

　　On February 2nd, the film "The Blind Road" was released, and Li Yang said that it was quite appropriate to release a film directed by the second director on such a "second" day.

　　Under the impact of several Spring Festival movies, Blind Road, which was released for six days, was not optimistic in several Spring Festival movies released at the same time. The proportion of film arrangement is 0.21%. As Li Yang said in an interview, "I have no expectations for the box office. I only hope that people with thinking can see this film. " Some fans criticized "the lack of sharpness, the warmth, and the dubbing of lines." Some fans questioned, "Where is the style that used to be as sharp as a scalpel? Why has Blind Road become so warm?" "Is Li Yang the last of Jiang Lang" and so on.

　　In the face of criticism from fans, Li Yang wrote a letter of apology to the fans. In the letter of apology, Li Yang wrote: "I admit that I made a lot of changes and compromises to meet the audience for this film. Many places are not satisfactory, and I am not very satisfied with this "Blind Road". I know you expect me to make movies as powerful as The Furnace and Su Yuan. Here I would like to make a deep bow to my fans and say I’m sorry! I let you down! !”

　　During the filming process, Li Yang used his little savings and mortgaged to borrow money to shoot Blind Road. During the filming period, the funds were broken and he was on the verge of bankruptcy. Finally, with the help of his good friends, entrepreneurs Su Tong and Guo Yukuan, and a famous entrepreneur who didn’t want to sign, he completed the production of Blind Road. Everyone saw some unnatural "Uncle Liang" in the film. Because of his low salary, the actor who promised to play suddenly changed his mind and didn’t have time and capital to find another actor. Li Yang went into battle himself and finished a film written, directed and acted by himself.

　　When I saw Li Yang in the interview, I almost called him "Uncle Liang". Li Yang revealed that the "stepfather" in the film is the prop master of the crew, and the "criminal Guo Wei’s wife" is the record of the crew. They have never acted.

　　Director Li Yang is on the set.

　　In an interview, Li Yang expressed his anxiety, "I’m worried that the film hasn’t been finished and the money has run out." Li Yang is very honest. He invested his own money to make a film, so it can’t be due at last. The film was not finished, so the crew couldn’t afford to pay. "

　　Can The Blind Road Measure Li Yang’s Real Strength?

　　Blind Tao tells a story of redemption and self-redemption. Jingjing, a blind girl, has been controlled by a human trafficking gang headed by Guo Wei, begging for money on the street. Jingjing and Zhao Liang encounter, and they repel each other and guard against each other. Through a series of warm stories, they move each other and get together. Jingjing is a blind girl who was sexually assaulted by her stepfather, trafficked and begged in the street. Zhao Liang was a once brilliant rock singer who killed his daughter because of drinking, went to prison, and after he was released from prison, his heart was blocked and he was unwilling to communicate with the outside world. The encounter between them made each other feel the warmth of human feelings and realized the process of self-redemption.

　　Jingjing played by Du Hanmeng in the stills of Blind Road

　　I once talked to my friend about Li Yang, and my friend asked, "Which Li Yang? Crazy English Li Yang? " Li Yang should have become a legend, but now he is still a minority.

　　A director who won the German Silver Bear Award, in China, outsiders may not be familiar with Li Yang. But when it comes to Tsui Hark’s "Taking Tiger Mountain Outward", everyone knows that Li Yang is the screenwriter behind "Taking Tiger Mountain Outward". As far as storytelling ability is concerned, Li Yang can earn tens of millions by writing plays, but he didn’t do it.

　　Wang Baoqiang "Silly Root" changed his destiny because of his performance in Blind Well, and won the Golden Horse Award for Best Newcomer and the Best Actor Award in French and Thai Film Festivals. Huang Lu also became famous at home and abroad for his excellent performance in Blind Mountain. Later, Wang Baoqiang was chosen by Xiaogang Feng and took part in world without thieves. Later, his works such as Soldiers’ Assault and Man on the Road were well known. On the choice of actors, Li Yang has a keen and professional ability to choose actors.

　　With the film market environment getting better and better, whether writing a script or making a commercial film, Li Yang can make a lot of profitable films with his professional strength and ability to tell stories. However, it took him 16 years to make three minority films, Blind Well, Blind Mountain and Blind Road. Every movie is my own investment, and I can’t make any money in China.

　　In the first twenty years of Li Yang’s debut, only two feature films were left, Blind Well in 2003 and Blind Mountain in 2007. Some reports commented on Li Yang: "These two films alone are enough to occupy a place in the history of Chinese films, because from these two films, we can already see that his narrative talent, sense of social responsibility and criticism of reality have few opponents among contemporary directors."

　　Many fans expect Li Yang to make a movie like The Melting Pot. Li Yang told Entertainment Focus: "I can make a shocking movie like The Melting Pot at the right time and with permission." Under the existing conditions, he really tried his best.

　　Stills of the movie "The Blind Road"

　　It is reported that watching the blind road is like watching the report of Southern Weekend, and the source of the film Blind Road is a report about begging children in China that Li Yang read in Southern Weekend more than ten years ago. Li Yang visited more than half of China, interviewed schools for the blind, chatted with them, and even went to the juvenile detention center to get in touch with the minors who committed crimes, so as to understand their growing environment, and thus understand why these left-behind children committed these unbelievable criminal acts such as robbery, theft and beating. Their hearts are simple and contradictory.

　　If you have the ability to make money from movies, why not make commercial films?

　　When I was a child, my family was superior, and Li Yang, who had grown up in the entertainment industry, made a lot of money making commercial films, both professionally and storytelling. However, Li Yang chose to pay attention to the disadvantaged groups at the bottom, starting with Li Yang’s growing experience.

　　Li Yang was born in a drama actor’s family in 1959, and both his father and mother were drama actors. My father used to support the northwest as an expert. During Li Yang’s one-year-old to eight-year-old years, his family conditions were superior and he was influenced by art since childhood. However, during the Cultural Revolution, Li Yang’s father was persecuted to death, when Li Yang was only 13 years old. Compared with before, Li Yang’s life suddenly fell to the bottom. This also gives Li Yang the opportunity to reach out to the bottom and vulnerable groups, and is more sensitive to social injustice.

　　Mapping to the movie "The Blind Road", Zhao Liang, played by Li Yang himself, is a once brilliant down-and-out rock singer. From his glory to the change of life, it seems that his story is alluded to the movie plot. It is also a challenge to write, direct and perform, and to change roles between actors and directors. In order to save the cost, I have to do it myself. Only this sincerity should make the audience who spit out Li Yang’s acting more understanding.

　　"Blind Mountain" was shortlisted for the "One Concern" unit of the 60th Cannes Film Festival. It tells the story of female college students being trafficked to a French-blind mountain area and rescued many years later. Some reports commented on Lust Caution and Blind Mountain: "If Lust Caution shows the helplessness of the entanglement between men’s and women’s lust and sadness and state affairs through bed play, Blind Mountain is a modern evil expression of the rape of the heroine by all members of the family who are ignorant of law and barbaric."
Li Yang said that the topic of trafficking in women is not new, but he is concerned about the people behind the incident. At the beginning of 2006, Li Yang made a special trip to Chengdu Jintang and Zhongjiang, and spent more than two months interviewing the rescued abducted women’s living conditions and writing a script.

　　This year’s Blind Road has softened a lot, not because of Li Yang’s softening, but because of Li Yang’s compromise to show it to everyone. Otherwise, we may not even have a chance to see it. After the film was released, Li Yang apologized to the audience sincerely. Li Yang wrote in the letter of apology: "The film is not perfect because of economy and various reasons, and there are many regrets. But with the support of my friends, I went against the wind in an era when such flashy, illusory, spoof and hypocritical movies filled cinemas. I am worthy of my conscience and this era.

　　Postscript-It should be a legend, but it is still a niche.

　　Li Yang, who is nearly 59 years old, has bright eyes when interviewed. During chatting, he will also turn sideways to the reporter and say that he can’t hear clearly, so that the reporter can speak louder. We have seen Li Yang’s sincerity to reporters and audiences. It should be said that he is sincere to this era.

　　A former actor and professional director, relying on his own savings, mortgaged his house to make movies, and had no expectations for the box office. Just to let more people know about a social phenomenon. In Li Yang’s view, it is not terrible to have social trauma, but the most terrible thing is to cover it up. Let everyone see that our society will be better if we work together to solve bad things.
The feature of Li Yang’s films is to face reality directly, not to whitewash it.

　　In the film works of the past year, several word-of-mouth films, such as Gangrinboqi and Fanghua, which reflect human nature and are well-received, have appeared. Li Yang believes that fans will become rational and people themselves need spiritual needs. This trend in movies this year is a return of humanity and rationality.

　　The Blind Road is the final work of Li Yang’s "Blind" series. In the future, Li Yang will also make valuable commercial films. As Li Yang said: Our film and television works are not scratching, and movies are cultural products. I am totally opposed to art films and commercial films. All films are commercial films, and they are commodities from the day they are born, but they are commodities with cultural value, and the films themselves are cultural. "

I’ll bring this one to you today. Let’s take a look at its performance.

Let’s take a look at the appearance of Sylphy. The front face of Sylphy is very round, and the middle net adopts a multi-spoke shape, which looks sporty. Coupled with the steady headlights, the overall look is deep. The car is equipped with LED daytime running lights, automatic opening and closing, etc. Coming to the side of the car body, the size of the car body is 4631 mm * 1760 mm * 1503 mm. The car uses simple lines, and the side of the car feels very cute. With large-sized thick-walled tires, it gives people a very elegant feeling. In the rear part, the overall shape of the Xuanyi rear echoes the front face, the taillights are very atmospheric, and the layout of the exhaust pipe uses a hidden shape, creating a good gas field.

Sitting in the car, the interior style is very simple and very spirited. The car’s three-spoke steering wheel is simple in shape, equipped with functions such as manual adjustment of the steering wheel up and down, and the shape is very fighting. Let’s take a look at the central control, which is decorated with an 8-inch central control panel, which makes the interior design quite layered and the overall design of the central control is remarkable. Finally, let’s look at the dashboard and seats. The dashboard design is remarkable and the information reading is simple and clear. The car adopts imitation leather seats, which are wide and thick and comfortable.

Sylphy is matched with CVT gearbox, with an acceleration time of 12.1s per 100 kilometers, which has good power performance and is completely OK for daily use.

The space performance of Sylphy trunk is ok. If there are big items during the trip, you can put down the rear seats to expand the space. At the same time, the car is equipped with anti-lock braking (ABS), LED daytime running lights, brake assist (EBA/BAS, etc.), braking force distribution (EBD), traction control (ASR/TCS, etc.), main driving airbag, co-pilot airbag, side airbag curtain, front side airbag and other safety configurations.

The moderate size of the car is a very suitable choice for many families, and the internal space is enough for daily use in families. If you are going to buy a car, you might as well think about it.