China National Intellectual Property Administration decided to open a unified identity authentication platform for patent and integrated circuit layout design business at 9: 00 am on December 12, 2022.

Website: https://tysf.cponline.cnipa.gov.cn/am.

The platform is connected with the "Patent Business Processing System" which was launched in January 2023, and realizes unified management and unified identity authentication of registered user accounts of existing patent electronic applications, electronic bills, patent affairs services, electronic application platforms for integrated circuit layout design, PCT international applications, and international applications for design. Before the "Patent Business Processing System" went online, the above business systems were operating normally.

According to the requirements of the Network Security Law of the People’s Republic of China, the Personal Information Protection Law of People’s Republic of China (PRC), the Decision of the Standing Committee of the National People’s Congress on Strengthening the Protection of Network Information and other laws and regulations, registered users of all systems are requested to log in to the platform in time, check and re-sign the user registration agreement, improve the user registration information and bind the mobile phone number. Registered users of legal persons and registered users of agencies should be associated with managers. For details, please refer to Operation Manual for Improving User Information (Annex 1) and FAQ (Annex 2). After improving the above user information, registered users can continue to handle patent business after the "patent business handling system" goes online.

The platform will follow the principles of legality, justness and necessity, and properly keep and use user information in accordance with laws and regulations.

I hereby inform you.

Attachment: 1. Improve the user information operation manual. pdf

　　　　　　　　　 2. Frequently asked questions. pdf

China National Intellectual Property Administration

December 7, 2022

Recently, Chezhi. com learned from relevant channels that Toyota officially released the official map of Hatchback FX Special Edition. It will land in the US market in the autumn of 2025, with a limited sale of 1,600 vehicles. With reference to the regular SE model, which starts at $23,780 (about RMB170,000), FX Special Edition is expected to have a small premium.

In terms of appearance, the new car is based on the US version of Corolla Hatchback entry SE, inspired by the 1987 FX16 model, which combines retro design elements with modern sports aesthetics. The body is available in three exclusive colors: midnight black metallic color, ice cap white and underground gray, with 18-inch white aluminum alloy wheels (the same as the Nightshade version) and a black tail spoiler. The overall shape is full of tension style. The front face is blackened, the honeycomb mesh and LOGO are blackened, and the tail is designed with single-side double-exhaust and blackened metal trim to create a strong sports atmosphere.

In the interior, the new car is equipped with an orange stitched Moonstone sports fabric seat, with a shift lever covered with suede and a retro air conditioning knob. The details incorporate retro feelings and performance elements. The central control area adopts a 10.5-inch floating screen, which supports CarPlay and voice control, and the response time is shortened to 0.3 seconds. In terms of safety configuration, Toyota Safety Sense 3.0 system is standard, which integrates pre-collision assistance, adaptive cruise and other functions. At the same time, it is equipped with wireless charging, four USB interfaces and heat insulation and sound absorption materials, taking into account technology and practicality.

In terms of power, FX Special Edition is equipped with a 2.0L four-cylinder naturally aspirated engine (code 3ZR-FE), with a maximum power of 124kW and a peak torque of 204N·m, matching the CVT gearbox. Although the parameters are biased towards daily use, the throttle response and shift logic are optimized, which makes the daily driving smooth and fuel-efficient, and has a good sense of linear acceleration when stepping on the throttle deeply. In terms of chassis, the new car adopts short shock absorber spring and sports suspension setting, which effectively improves cornering stability and steering feedback. For more information about the new car, the car quality network will continue to pay attention to and report.

Today (December 10th), the National Health and Wellness Commission held a press conference to invite relevant experts to introduce the prevention and treatment of respiratory diseases in winter in China. Xia Gang, director of the Department of Health and Immunity of the National Bureau for Disease Control and Prevention, said that influenza vaccination is an effective means to prevent the onset of influenza and reduce influenza-related severe illness and death.

In the early stage, the National Bureau for Disease Control and Prevention has made special arrangements for promoting influenza vaccination. This year’s supply has the following characteristics.

First, the supply is early. The relevant departments jointly acted to optimize the procedures to buy time for ensuring the vaccine supply in place before the epidemic season. Since July, vaccination units around the country have started influenza vaccination services one after another, earlier than the influenza epidemic season.

Second, the supply is sufficient. Improve the ability to ensure the supply of influenza vaccine. This year, the production and supply of influenza vaccine has increased significantly compared with last year, which can meet the vaccination needs of the masses at this stage.

The third is to re-implement. Dispatch and deploy many times to guide all localities to actively promote influenza vaccination in accordance with the principle of informed consent. In the follow-up, we will continue to guide all localities to estimate the demand for influenza vaccination, optimize the rational distribution of vaccines, achieve accurate planning and use, and actively work with relevant departments to strengthen the connection between vaccine supply and demand to ensure that the supply of influenza vaccines is uninterrupted and the people have vaccines to vaccinate.

At the same time, we will further enrich the forms of publicity, increase publicity efforts, and guide all localities to provide timely, convenient and high-quality influenza vaccination services by making appointment registration, carrying out time-sharing vaccination, extending the vaccination cycle, and increasing service hours. Here, I once again call on everyone to be active, proactive and vaccinate as soon as possible, which is not only to protect themselves, but also to protect their families around them. (CCTV reporter Shi Yingchun Kong Luyuan)

　　I. Overall operation

　　The growth rate of software business revenue rebounded slightly.1— In October, China’s software business revenue was 8,421.4 billion yuan, up 10.0% year-on-year, and the growth rate was 0.2 percentage points higher than that in the previous three quarters.

　　The growth of total profit accelerated.1— In October, the total profit of the software industry was 1,004.7 billion yuan, a year-on-year increase of 4.5%, and the growth rate was 1.8 percentage points higher than that of the previous three quarters.

　　Software business exports grew steadily.. 1— In October, the export of software business was US$ 42.7 billion, up 5.1% year-on-year, and the growth rate dropped by 0.6 percentage points compared with the previous three quarters, among which the export of software outsourcing services increased by 10.1% year-on-year.

　　Second, the sub-field operation

　　The revenue growth rate of software products increased slightly.. 1— In October, the revenue of software products was 2,073.7 billion yuan, up 9.6% year-on-year, and the growth rate was 0.2 percentage points higher than that of the previous three quarters, accounting for 24.6% of the total industry revenue. Among them, the income from industrial software products was 186.1 billion yuan, up 12.8% year-on-year.

　　Information technology service revenue maintained rapid growth.. 1— In October, the revenue from information technology services was 5,458.3 billion yuan, up 10.1% year-on-year, and the growth rate was the same as that in the first three quarters, accounting for 64.8% of the total industry revenue. Among them, cloud computing and big data services realized a total revenue of 823.4 billion yuan, a year-on-year increase of 7.7%, accounting for 15.1% of information technology service revenue; The revenue from integrated circuit design was 228.6 billion yuan, up 13.0% year-on-year; The technical service income of e-commerce platform was 838.6 billion yuan, up 16.5% year-on-year.

　　The growth rate of information security revenue has been steady and falling.. 1— In October, the revenue of information security products and services was 154.9 billion yuan, up 9.7% year-on-year, and the growth rate dropped by 2.7 percentage points compared with the previous three quarters.

　　The revenue growth of embedded system software accelerated.. 1— In October, the revenue of embedded system software was 734.4 billion yuan, a year-on-year increase of 9.6%, and the growth rate was 1.2 percentage points higher than that of the previous three quarters.

　　Third, the operation by region

　　The income of software business in the eastern region has accelerated, and the growth in the central region is leading.. 1— In October, the revenue from software business in the eastern region was 6,946.4 billion yuan, up 9.4% year-on-year, and the growth rate was 0.2 percentage points higher than that in the previous three quarters. The revenue from software business in the central region was 404.5 billion yuan, up 14.7% year-on-year, 4.7 percentage points higher than the overall level of the whole industry; The revenue from software business in the western region was 883.1 billion yuan, up 13.0% year-on-year, 3 percentage points higher than the overall level of the whole industry; The revenue from software business in Northeast China was 187.4 billion yuan, up 8.5% year-on-year, and the growth rate dropped by 0.2 percentage points compared with the previous three quarters. The software business income in the four regions accounted for 82.5%, 4.8%, 10.5% and 2.2% of the total national income respectively.

　　The revenue proportion of major software provinces increased slightly.. 1— In October, among the top five provinces in software business income, the software income of Beijing, Guangdong, Jiangsu, Shandong and Shanghai was 1,757.4 billion yuan, 1,431.9 billion yuan, 1,054.1 billion yuan, 843.3 billion yuan and 716.2 billion yuan, respectively, with an increase of 8.5%, 10.3%, 7.0%, 17.9% and 716.2 billion yuan.

　　The revenue of software business in central cities has increased steadily.. 1— In October, the software business income of 15 sub-provincial central cities nationwide reached 4,223.7 billion yuan, up 8.4% year-on-year, with the growth rate increasing by 0.1 percentage point compared with the previous three quarters, accounting for 50.2% of the national software business income, down 0.7 percentage point compared with the same period last year. Among them, the growth rate of software business income in Ningbo, Wuhan, Jinan, Qingdao, Dalian, Xi ‘an and Xiamen exceeded the overall growth rate of the whole industry.

Cartography: Zhang Fangman

If you open the column,

Without national health, there will be no overall well-off society. At the National Health and Wellness Conference held recently, General Secretary of the Supreme Leader emphasized that people’s health should be placed in a strategic position of giving priority to development, and efforts should be made to ensure people’s health in an all-round and full-cycle manner. Promoting the construction of a healthy China is a solemn commitment of the Party to the people, and it is also an important livelihood project and popular project. Starting from today, this newspaper will open a column of "Healthy China", reporting vivid practices and typical experiences of various localities and departments from all directions and angles around key tasks such as popularizing healthy life, optimizing health services, improving health protection, building a healthy environment and developing health industries, advocating a healthy and civilized lifestyle, guiding the whole society to establish a sense of great health, making the concept of healthy China deeply rooted in people’s hearts, and supporting a well-off society in an all-round way with the health of the whole people.

It is difficult and expensive to see a doctor, and a question about people’s livelihood affects hundreds of millions of people.

The people have a call, and the government should respond. After the start of the new round of medical reform, especially since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the supreme leader as the general secretary has stood at the strategic height of the long-term development of the Chinese nation, comprehensively deepened the reform of the medical and health system, and insisted on ensuring the basics, strengthening the grassroots and building mechanisms. The reform has changed from individual soldiers to coordinated advancement, and the policy superposition effect has gradually emerged, and the difficulty and expensive medical treatment have been significantly alleviated, and the people have more sense of gain and happiness. The proportion of urban and rural residents’ personal health expenditure in the total health expenditure continues to decline, with minor illness, serious illness and serious illness guaranteed, and the health level continues to improve, and the whole people share the "health dividend".

Practice has proved that sticking to the Chinese way to solve the worldwide problem of medical reform has opened up a road of health and healthy development in line with national conditions and provided a strong support for a healthy China.

Graded diagnosis and treatment saves money and worry-

200 cities to carry out family doctor contract service

"Save money, time, effort and worry!" Speaking of the benefits of graded diagnosis and treatment, Ding Qiming, a retired old man in Gulangyu Community, Xiamen City, Fujian Province, smiled. Ding Qiming, 77, suffers from chronic diseases such as diabetes and hypertension. With the help of a team of family doctors, hypertension, hyperglycemia and hyperlipidemia have all stabilized. "Now I walk briskly."

Ding Qiming told reporters that before the reform of graded diagnosis and treatment, Gulangyu had few medical staff, low level and incomplete drugs. No one believed that the disease could be cured on the island and they all went to the big hospitals in the city to see a doctor. By boat, by car and queuing for registration, it takes half a day to see a doctor, which is very painful. If the ferry stops in bad weather such as typhoon, you can’t go to the other side. After the implementation of graded diagnosis and treatment, residents can see a doctor in the community hospital on the island, avoiding the fatigue of travel. Ding Qiming said: "In the past, my heart was not good. I have seen it in major hospitals and the treatment was ineffective. The community arranged an expert consultation for me, and one-on-one careful treatment, and my situation soon stabilized. "

"Chronic diseases first, linkage from top to bottom, and joint management by three divisions" is a graded diagnosis and treatment model actively explored by Xiamen, which realizes the shift of the focus of health work. Large hospitals are "willing to let go and let go", primary medical and health institutions are "willing to take over and stay" and the masses are "willing to go and stay". Yang Shuzhen, director of the Xiamen Municipal Health Planning Commission, said that the "three divisions" refer to specialists in large hospitals or specialized hospitals, general practitioners in grass-roots institutions and health managers from grass-roots units. The patient signed a contract with the "Third Division" to obtain family doctor services. The signing fee is 120 yuan every year, of which 100 yuan is borne by medical insurance, and residents only need to pay 20 yuan. With the implementation of the "three divisions co-management" model, the "wartime state" of long-term overcrowding in large hospitals has obviously eased. In 2015, the average waiting time for tertiary hospitals in Xiamen was reduced from 40 minutes to less than 10 minutes.

Since the start of the new round of medical reform, the construction of graded diagnosis and treatment system in China has been promoted in an orderly manner. All localities focus on improving the ability of primary medical services, and take common diseases, frequently-occurring diseases and chronic diseases as breakthroughs to gradually guide the sinking of high-quality medical resources. More than 1,600 tertiary hospitals across the country have established counterpart support relations with more than 3,800 county-level hospitals, and strive to make ordinary people look after their illness at their doorsteps, forming a virtuous circle of "minor illness at the grassroots level, serious illness at the hospital, and rehabilitation back to the grassroots level". This year, 200 pilot cities for comprehensive reform of public hospitals will carry out family doctor contract service. By the end of the year, the coverage rate of urban family doctor contract service is expected to reach more than 15%, and the coverage rate of key population contract service will reach more than 30%.

Liang Hong, a professor at the School of Social Development and Public Policy of Fudan University, pointed out that it is an important measure to set up a contract service system for family doctors in line with China’s national conditions and form a medical treatment model of "first consultation at the grass-roots level, two-way referral, quick and slow division and up-and-down linkage". Only by changing the supply mode of medical and health services and the behavior of people seeking medical treatment can the medical center of gravity return to the grassroots level, and the goals of controlling medical expenses, improving health management effect and improving service satisfaction can be achieved.

Serious illness insurance is a timely help-

The actual reimbursement rate increased by 10 percentage points.

Recently, Ms. Wang from Jiaozuo, Henan Province, came to the People’s Hospital of this city to receive the money reimbursed by her husband during his lifetime. Previously, her husband died in hospital due to septic shock, with a total cost of more than 208,000 yuan, excluding more than 110,000 yuan for reimbursement of new rural cooperative medical insurance and serious illness insurance, and more than 17,000 yuan for reimbursement of serious illness supplementary medical insurance, which is a special preferential medical treatment for people in need in Jiaozuo City. Up to now, there are nearly 900 people in difficulty who have been reimbursed by supplementary medical insurance for serious illness in the city.

Supplementary medical insurance for serious illness is the third level of medical insurance after basic medical insurance and serious illness insurance. Jiaozuo City will link the supplementary medical insurance for serious illness with the basic medical insurance and serious illness insurance. If the hospitalization expenses of the needy people are less than 15,000 yuan after being reimbursed by the basic medical insurance, they will be reimbursed by the supplementary medical insurance for serious illness; More than 15 thousand yuan, urban and rural residents’ serious illness insurance compensation, by the serious illness supplementary insurance to give a second reimbursement.

Ning Ji, executive deputy director of Jiaozuo Medical Reform Office, said: "The supplementary medical insurance for serious illness has increased the reimbursement rate of the whole medical expenses by 10% to 15%, and the personal burden has dropped below 25%, which is a timely help to the needy people."

Since the start of the new round of medical reform, China has built the largest basic medical security network in the world in a relatively short period of time, achieving full coverage of the basic medical insurance system. Among them, the financial subsidy standard for basic medical insurance for urban and rural residents has increased from 80 yuan per capita in 2008 to 420 yuan in 2016. In 2015, the reimbursement rate of hospitalization expenses within the policy scope was about 81% for employees’ medical insurance, and about 75% for urban residents’ medical insurance and the new rural cooperative medical system.

Full implementation of serious illness insurance for urban and rural residents is an important institutional arrangement to solve the poverty caused by serious illness. In 2015, more than 4 million seriously ill patients benefited and paid 24.4 billion yuan for serious illness insurance. The actual reimbursement rate of seriously ill patients has generally increased by more than 10 percentage points on the basis of basic medical insurance, and the phenomenon of poverty caused by illness has been effectively alleviated. At the same time, establish a disease emergency rescue system. By the end of 2015, more than 400,000 acute and severe patients with unknown identity or inability to pay had been rescued. Medical assistance for serious and serious diseases will be widely carried out, and the target of assistance will be expanded from low-income recipients and destitute dependents to low-income recipients and seriously ill patients from poor families due to illness.

Online registration is easy to see a doctor-

The appointment rate of tertiary hospitals reached 32.1%.

This summer, Zhang Yanjun from Datong, Shanxi, took his son to Beijing Children’s Hospital. According to old experience, if you hang an ophthalmologist number, if you don’t find a "number trafficker", you will have to queue up in the middle of the night, sometimes even for a few nights. Therefore, he even prepared the Mazar and the mattress. To Zhang Yanjun’s surprise, the registration hall that used to be like a farmer’s market became very quiet. On the self-service machine, he easily hung up the expert number of the next day.

Since September 1, Beijing Children’s Hospital has cancelled the registration of outpatient windows and implemented a comprehensive appointment for non-emergency treatment. This means that except for emergency, all patients need to make an appointment through mobile APP, WeChat, telephone, internet or on-site self-service machine. The Beijing Municipal Hospital Administration said that 22 top three hospitals will cancel on-site registration this year and implement a comprehensive appointment system for non-emergency treatment. In the future, the "long queue of registration" in Beijing’s top three hospitals is expected to disappear, and patients no longer have to wait in line to register.

In 2015, the National Health and Family Planning Commission issued the "Action Plan for Further Improving Medical Services", and decided to use three years to strengthen medical management, improve service processes and innovate measures to facilitate people’s medical treatment in the national medical and health system, so that people can truly feel the effectiveness of medical reform. By the end of 2015, 1,238 tertiary hospitals across the country had established information bases to provide information inquiry and push services for patients; 660 tertiary hospitals settle accounts through mobile APP, WeChat payment, etc., reducing the number of patients queuing and shortening the queuing time. This year, tertiary hospitals across the country will fully implement appointment diagnosis and treatment services and provide a variety of appointment diagnosis and treatment methods.

With the popularity of "internet plus Health Care", online registration, remote consultation, mobile phone inquiry, mobile payment, etc., patients’ medical experience has been significantly improved. Jin Xiaotao, deputy director of the National Health and Family Planning Commission, said that making health data "run more roads" and making people "run less errands" is the development direction of big data application in health care. Based on the contract service of family doctors, China will basically realize that urban and rural residents have standardized electronic health records and fully functional health cards, and focus on promoting the application of Internet health consultation, online appointment and triage, medical insurance network settlement in different places, and expanding the service capacity of medical institutions.

Cao Xuetao, president of China Academy of Medical Sciences, said: "Using health care big data to expand service channels, extend and enrich service content can better meet the health needs of ordinary people." In 2020, everyone in China will have electronic health records and health cards, which will be the largest health big data in the world. In the future, everyone’s data from birth to death will be completely recorded, which will help to build a service system integrating prevention, treatment, rehabilitation and health management, and provide life-cycle health services for 1.3 billion Chinese. (Reporter Bai Jianfeng Shen Shaotie)

　　On June 22nd, Wei Shufen was broadcasting "Bringing Goods" live. Photo courtesy of respondents

　　On May 27th, An Qiujin conducted a live broadcast of "bringing goods" for local agricultural products in Guizhou. Photo courtesy of respondents

　　The competition in the future will definitely become more and more fierce. Creative and thoughtful anchors are more likely to pop up and go further. Speculators may pop up suddenly, but they will be silent soon.

　　"After a year or two or three years, I haven’t got a fire yet, so I must consider changing careers." Zhou Han, a post-00 girl who is currently living in a media company in Yiwu, Zhejiang Province, said.

　　She is a freshman majoring in modeling and etiquette in Yiwu Vocational and Technical College of Industry and Commerce. She looks sweet, likes "two yuan" and is good at dancing. About three months ago, her college cooperated with this media company to cultivate e-commerce live broadcasters. Zhou Han quickly became famous. "Now e-commerce live broadcasts are so hot, and when the opportunity comes, we must seize it."

　　On May 8th, she took the "E-commerce Live Broadcasting Special Professional Ability Certificate" issued by Yiwu Municipal Bureau of Human Resources and Social Security, and considered e-commerce anchor as her future formal career. Soon, her profession had a name of "official certification" — — Live Salesman is a type of work under "Internet Marketer", one of the 10 new occupations to be released in Ministry of Human Resources and Social Security.

　　"A job with at least 5,000 employees can be called a career." Pu Yongxiang, director of the Vocational Skills Evaluation Center of China National Light Industry Federation, said that there are nearly 8 million Internet marketers at present, and it is expected to reach 15 million this year. "The gap is about five or six million."

　　Recently, the "Report on Live Delivery Talents in the First Half of 2020" released by BOSS, a recruitment platform, shows that in the first half of this year, the demand for talents in the main positions of "live stream economy" format reached 3.6 times that of the same period in 2019, and the number of job seekers flooding into the industry also reached 2.4 times that of the same period last year. At present, many young people have aimed at this "gap" or "outlet" and have begun to explore their way forward in this new profession.

　　Important people set up, but also product quality.

　　The job of "anchor" was originally like this in Zhou Han’s imagination: dress yourself up, turn on the camera and chat with netizens in the live broadcast room. Sometimes when I see the anchor who can’t speak and doesn’t move "like an oil painting" on the screen, Zhou Han thinks, "I must be better than them, at least I won’t stop talking."

　　However, during the first trial broadcast, when the camera was aimed at him and the light hit him, Zhou Han found that "I can’t speak myself", and only two or three netizens came to the live broadcast room, and "I won’t talk to anyone". "The live broadcast is far more complicated than expected, and there is a lot to learn".

　　In the following month, Zhou Han’s media company trained her for about one month, from the "rules of the game" of the live broadcast platform to the live broadcast process, from live script writing to dance and makeup. In the end, the company’s "personal design" for her based on her market and her personal situation is "the second girl". In Zhou Han’s view, "setting up a person" is the first step to run an account, like a road sign for the future development direction. "You can’t ‘ Second dimension ’ I’m going to cook food tomorrow. ‘ People set up ’ It is your own positioning. "

　　To say "people set up", the post-95 young man An Qiujin should be regarded as "the comic coffee in the food circle and the rapper star in the comic circle". Compared with the name An Qiujin, many netizens may be more familiar with his other name "poor cuisine" — — Wearing a black blouse, wearing a pair of round-rimmed sunglasses and holding a folding fan that says "Eat on time", he has been trying to make short videos since 2018, and now he is a gourmet with millions of fans. In his view, it is better to show a more authentic self than to set up a "person". "Some things, such as the love of food, can’t be installed, and netizens can see through you at a glance."

　　An Qiujin loved cooking since he was a child. Others watched cartoons on TV, and he watched cooking programs. After graduating from Tan Kah Kee College of Xiamen University in his senior year, he was invited by his seniors to join his MCN (abbreviation of multi-channel network, a product form of multi-channel network — — Editor’s note) Miracle Mountain, the company, "The company also found that I love cooking, rapper and so on, and finally chose the vertical field of food".

　　Of course, "bringing goods" means keeping "goods" well.

　　Wei Shufen, a live broadcast "Daren" who mainly recommends interesting food in the office, has adhered to the principle of "you must try it before you can recommend it" since the live broadcast in 2018. I don’t know how many snacks I have tasted for the "selection", and my weight has also increased by more than 10 kilograms. "In addition to the taste, we have to look at its ingredients, origin, etc., and then talk to the merchants about discounts to see if we can win more discounts for friends in the live broadcast room." Wei Shufen told reporters that the anchor should stand in the position of netizens and give them a good pass. "If the taste is bad or the price is too high or the food quality is not guaranteed, we will directly refuse. If there are good products, we will also take the initiative to talk to merchants about cooperation, and some will run back and forth for a long time. "

　　It is not uncommon for the live broadcast to "roll over" due to product quality problems. Pu Yongxiu also reminded people who want to enter this industry to have certain choices about products. "A few years ago, some platforms sold ‘ Three noes ’ Products, such as masks, cause irreparable harm to users. Marketers should reduce the occurrence of such things, abide by laws and regulations, including the Advertising Law, not vicious competition, and not use extreme language. "

　　Creative and thoughtful anchors are more likely to pop up.

　　If the live broadcast "bringing goods" is a popular competition, then the short video production on weekdays is a popular "accumulation". "Rising fans still depends on videos. If you have a video that suddenly explodes, your fans will rise quickly." Almost every day when I open my eyes, Zhou Han begins to think, "What video do you want to send today?"

　　To this end, she will learn to dance popular dances, learn to match videos with popular background music, constantly brush other people’s videos or live broadcasts and try to find pink skills from them. She will be anxious about the high and low "traffic" and will be more nervous when she sees new people entering the company. She will also find reasons for continuing to stick to it from the circuitous rise of video playback and praise, and will feel the "sense of value" in the commission of several hundred yuan distributed by the platform and the company. Her biggest wish now is that fans can break through ten thousand, although she is still a little far from this goal.

　　But even with 5 million fans, Wei Shufen still can’t escape the anxiety about how to continue to grow. "I haven’t seen much increase in powder for two weeks, and the situation is already very serious … … Now is a bottleneck period. " What went wrong? She thought maybe it was the audience’s aesthetic fatigue. How to break through? She hasn’t decided yet, although she will think about eating and walking, and sometimes she will think about insomnia. But I still got up at 7 o’clock the next morning to make up, shoot videos and broadcast live, and then worked overtime until after 10 o’clock. She said, "There is a feeling that I can’t stop now." Although I don’t know what the future holds.

　　"You don’t know what netizens really like. Maybe they like this one today and that one tomorrow. Hot spots are fleeting and it’s too difficult." Zhou Wei told reporters that if the number of broadcasts and likes drops, the traffic supported by the platform will be reduced. "Such a mechanism or rule will constantly force you to find a way."

　　In a similar state, An Qiujin has experienced twice: the first time, when the number of fans reached 600,000, he began to stagnate. He remembered that he and the team had not taken a day off for 72 days after that, shooting every day and trying to find a way. One day, he happened to see a "shop assistant" blouse in the company, put it on his body and suddenly had an idea — — Spend tens of dollars to pull a piece of black cloth as the background, put on an antique blouse, change the original "rap" into "storytelling", polish the food commentary, and strengthen the rhythm of the video … … Last stand’s plan was made. "If you don’t succeed this time, you will change careers and go home to find a job or take an examination of a civil servant.".

　　Unexpectedly, since then, the number of fans has risen to more than 1 million. After continuous updating for a period of time, the growth of fans reached the "bottleneck" again, and An Qiujin’s team upgraded the content again. Now his total number of fans on the whole network has exceeded 30 million. But when she really became popular, An Qiujin was not "relieved", but was even more stressed. "You will think more and have more concerns." "To tell the truth, I am afraid of being eliminated … … What you can do is to constantly adjust yourself and move forward. "

　　"No matter how many fans you have, once your content stops creating and innovating, the data will be very poor." A staff member of MCN Company told the reporter that his company has hatched many accounts. "What is summed up is not the methodology of making accounts, but the cultivation of ‘ Net sense ’ I know more about what people like to see and what they don’t like to see. " In her view, the competition in the future will definitely become more and more fierce. "Creative and thoughtful anchors are more likely to pop up and go further. Speculators may pop up suddenly, but they will be silent soon."

　　Zhongqingbao Zhongqingwang reporter Sun Qingling Li Guijie

This is the second city deeply excavated by "the most city THECITY"

long time ago

Drinking is a very interesting thing.

Singing to wine, life geometry

Do your best to maintain the interests without entanglement.

A lively scene of wine and ear fever

Only the feelings that are all in the wine are deep and righteous.

Like yellow rice wine just brewed, it tastes rough.

Over the years, it has become more fragrant and mellow.

This is gentle and elegant, which belongs to yellow rice wine.

Yellow rice wine has ruled China drunkards for thousands of years ~

As one of the three ancient wines in the world.

China’s unique and oldest wine old online celebrity.

Its scenery history far exceeds that of liquor, and there is a poetic cloud:

"The price of yellow rice wine rises when you buy it, and the price of white wine rises when you buy it cheaply."

Maybe Maotai at that time was just drinking excitement.

Chinese wine despises the non-mainstream at the bottom of the chain

(ps. The real popularity of liquor was after the founding of the People’s Republic of China)

And the unique brewing conditions that cannot be reproduced.

It also makes Japanese people who love wine unable to copy the same Shaoxing wine so far.

Even the brewing of sake in Japan borrowed from yellow rice wine.

The unique brewing technology is a model for the oriental brewing industry.

Traditional brewing technology of yellow rice wine in China;

Soaking rice, steaming rice, drying rice, fermenting in vat, raking, fermenting in jar, frying and packaging.

In this issue, we went to Shaoxing Ke Qiao and visited the only one in China.

Tapai Yellow Rice Wine Winery Insisting on Hand-brewing Yellow Rice Wine

I chatted with Mr. Pan Xingxiang, a master of non-legacy winemaking.

Past lives’s love and hate, the true meaning of the "former national wine" yellow rice wine

　1.

Drive into Hutang Town, Ke Qiao.

I smelled the aroma of the old wine.

Stepping into the winery, rows of old jars piled up like the Great Wall.

"Old wine is made of glutinous rice, and it becomes nou nou (pig) after drinking it."

This nursery rhyme, which is about to be lost, has been engraved into the DNA of several generations of Shaoxing people.

I always remember a little girl with a croissant braid.

Playing with friends, catching chickens and jumping with rubber bands.

Through the old Shaoxing winery, playing in front of the old altar …

There is a very interesting word in this nursery rhyme: "nou nou nou"

It is not only a nickname for children, but also describes the state of drinking old wine.

Zhou Zuoren used "pork" in his essays.

To indicate "nou nou" means a comfortable and happy state.

Perhaps this is the most appropriate impression given by Shaoxing yellow rice wine.

Liquor is spicy and dry, while beer is bitter and bitter.

The entrance of yellow rice wine is sweet and waxy, and the throat is warm and moist.

Not strong or light, mellow and long, comfortable and harmonious.

　2.

Yellow rice wine is often called "old wine" and "Shaoxing wine"

Old wine permeates the history of ancient Vietnam.

When Gou Jian, the King of Yue, endured humiliation and took revenge.

Pour the wine given by the people into the river, and the whole army will drink it together

The military and civilians defeated Wu in one fell swoop, which is known in history as "the teacher who threw the mash"

The river into which wine was poured was called "Toulao River" by later generations.

Still flowing in the ancient city of Shaoxing …

Old wine, drunken romantic figure

Without it, maybe half the sky of China art will collapse.

Settled in Shaoxing in his later yearsWang Xizhi, bring friends to bend the water and flow.

Write down "the best running script in the world" and "Preface to Lanting" while drinking.

Lu youIn Shenyuan, I met Tang Wan, the ex-wife who married someone else.

With mixed feelings, the poem "Hairpin Phoenix" was written on the wall.

"Red crisp hands, yellow wine, spring willows in the city."

Every inch of acacia turns into that "cup of sadness"

Yue Opera Lu You and Tang Wan

Huiji BrewmasterHe Zhizhang, with poetry fairy.li poregret we didn’t meet sooner

Do not hesitate to trade scarabs for wine, and get drunk for a good time.

The originator of freehand brushwork of flowers and birds that influenced Qi Baishi.Xu WeiExchange paintings for drinks.

Life "don’t envy the emperor, don’t envy immortals, drinking is better than living immortals"

Jianhu Nvxia in the Republic of ChinaQiu Jin, "Diao Qiu for wine is as good as Hao."

There are also people written in wine.Lu Xun, every meal will be wine.Cai Yuanpei

Drunk in the yellow wine bathtub, let go of the drinka surnameandlin qingxuan

Gu Long: "Love is not the taste of wine, but the friend when drinking."

The story soaked with yellow wine will always taste good.

After perseverance, the pleasure of kindness and hatred, the free and easy and broad-minded literati in troubled times.

Love is not the parting from sorrow, and the bliss of drinking with your bosom friend.

The heroic ambition of the heroine, the alternative rebellion of sending affection to wine.

The ups and downs of several dynasties, the personnel wasted, all in the wine.

　3.

Without Shaoxing, there would be no rice wine.

Shaoxing gave yellow rice wine a unique soul.

As one of the oldest wines in the world.

Yellow wine, beer and red wine are also called the three ancient wines.

In the Shang and Zhou Dynasties 3,000 years ago,

Chinese created the complex fermentation method of distiller’s yeast and began to brew a large number of yellow rice wine.

Yellow rice wine has a wide producing area and many varieties, and Shao Huang is the most famous one.

Pan Xingxiang, an intangible winemaker at Tapai Winery, told us

The ancient handmade yellow rice wine has to go through at least one year of wind and rain.

Make wine medicine in summer and wheat koji in autumn.

Brewing in winter, pressing and frying in spring.

The "meat of wine" glutinous rice and "bone of wine" wheat koji in yellow rice wine.

"The blood of wine" is the water of Jianhu Lake, and the three are indispensable.

Jianhu water rich in trace elements

The content of "strontium" is much higher than that of ordinary water bodies.

Shaoxing is the only one of Jianhu water for brewing yellow rice wine.

Whether it is Chiang Kai-shek who brought rice wine to Taiwan Province

Or a foreign winery or a Japanese winemaker

Even with the introduction of Shaojiu koji imitation

Can’t brew a wine comparable to Shaoxing wine.

Japanese who love yellow rice wine drink old wine and now only import it from Shaoxing.

The most important reason is that they don’t have Jianhu water.

Jianhu water comes from Shaoxing, and Maolin Xiuzhu in Huiji Mountain area.

The water is clear and rich in minerals.

Plenty of rain can ensure high purity all the year round.

Good water makes good wine, Shaoxing yellow wine nourished by Jianhu water.

The flow is empty and bright, and the color is like amber.

Besides good water, the season of brewing is also very important.

Traditional handmade yellow rice wine follows the principle of one winter and one brewing.

"The son should be his own, and the old wine should be brewed in winter."

From beginning of winter to beginning of spring in the following year.

Shaoxing people call this process of brewing yellow rice wine "winter brewing"

Qing "Zunsheng Eight Notes" cloud:

"beginning of winter, water phase; Winter solstice, water flourishing; Beginning of spring, Shuixiu … "

Winter is the most beautiful and best season for water quality.

The temperature is low, and miscellaneous bacteria can’t survive.

With less rain, the clear Jianhu water is of better quality at this time.

This slightly sweet lake with good water makes it "more wine in the world"

The ancient wine-making rules conform to the weather.

The drinking criterion is also based on the valuable practical experience of the people for thousands of years.

Yang dominates in summer and Yin dominates in winter.

Pay attention to Yin and Yang in Chinese in the cold winter.

Brewed Shaoxing wine, which is good for warming the yang.

Let your body "balance yin and yang"

Through a cold winter, it is for the unity of man and nature.

It is said that Deng Xiaoping is 85 years old and still insists on a glass of yellow wine every day.

4.

Yellow rice wine is the wisdom about water, time and life.

It is a low-key, but essential golden supporting role on the dining table.

Pan Xingxiang, the winemaker of Tapai yellow rice wine, has been making wine in three generations.

He said that when I was a child, my family would cook 50 kilograms of wine every New Year.

"Borrow bottles of wine on credit, and there is wine in the pot to keep customers."

"There is no wine at home. This is a pity for the guests."

Yellow rice wine is indispensable for the welcome and delivery in life.

Yuanxiao wine, shaving wine, Dezhou wine, house wine, birthday wine …

Warm drink for health, cool to relieve summer heat, add flavor with meals, and stir-fry into wine.

In this life, sooner or later, Chinese will meet with warm yellow rice wine.

"Old wine and preserved duck add, new wine and dried bean curd"

At the dinner table of Shaoxing people, there is a match between food and wine comparable to that of the West.

For example, among yellow rice wine, Yuan red wine is the most refreshing.

Suitable for cold dishes such as vegetables and jellyfish.

Rice wine is rich.

It is the number one CP for all kinds of meat and hairy crabs.

Sweet good wine, fragrant snow wine

It is the best partner of chicken, duck and beet.

The delicious food created by yellow rice wine is drunk shrimp and crab.

Can always subtly neutralize the coolness of lake crab shrimp

Distiller’s grains, residue left after brewing yellow rice wine

It is also often used by water people to make bad things, bad chickens, ducks and geese.

There is alcohol in the salty and fresh food. Chew it carefully and don’t have a flavor.

Bad food began more than two thousand years ago.

Follow us and check out the previous issue of "Shaoxing Goose"

5.

Long ago, drinking was a very interesting thing.

Singing to wine, life geometry

A dish of fennel beans, two or three friends, and several jars of old wine.

Now it has been stirred up by some people.

Be forced by the situation and show courage.

There is less truth in the wine.

Pua, the wine table, fell to no solution after some controversy.

"Peach, plum, spring breeze, a glass of wine, the night rain in the rivers and lakes for ten years."

I like these two poems very much, and I have no interest in them.

Try your best to maintain the lively scene of being drunk and hot.

Only the ten years of being in wine have deep feelings and heavy meanings.

Just like yellow rice wine, it tastes light and rough.

With the passage of time, the oxidation of wine body

Over the years, it has become more fragrant and mellow.

This is a gift of time, a gift of soil and water.

It is also a gentle and elegant rice wine, and it is easy.

Well-preserved jar-packed yellow wine has a long shelf life.

The same is true of the long-lasting love in the world.

After the fermentation of time and space, it becomes more and more precious.

Don’t drink too much, a little tipsy is better than getting drunk

May you drink just for fun.

Drunk, drunk, don’t forget the age.

Thank you for your patience. You saw the end.

The next preview of "the most city THECITY"

Nirenfa

Visual | Nickname Lost Writing | Roadside Leek Banana Editor | Roadside　

　

　　　　　　 CCTV News:Nowadays, fast services such as online ticket purchase and mobile payment are loved by more and more people, but there are hidden consumption traps behind the convenience. Recently, a large number of consumers broke the news that when buying train tickets on some third-party platforms, they always encounter the situation that train tickets are bundled and checked by default. According to the clues provided by consumers, the reporter had an experience on some commonly used third-party ticketing platforms.

　　　　　　 The reporter opened the ticket purchase page of Tongcheng Yilong train ticket in WeChat applet and chose a second-class high-speed rail ticket between Beijing and Tianjin. The fare display was 54.5 yuan. But when the reporter submitted the order, the price automatically became 77.5 yuan. What about the extra 20 yuan? Most users may not know that they bought a preferred service at the same time. Only after clicking on the preferred service can they see the extra 20 yuan high-speed ticket. Moreover, this high-speed ticket is hidden deeply, and it is difficult to find it without careful search. The reporter manually cancelled the overcharged 20 yuan, only to find that the routine of bundling sales by merchants did not end. Just as the reporter was preparing to pay, the page showed that the total order amount was 66.5 yuan, and it was indicated in small red letters that 2 yuan had been offered. It turns out that the system has checked the special service of so-called high-quality users with the train ticket discount coupon *4 by default, so that the cost is higher than the actual fare of 54.5 yuan in 12 yuan. Once consumers find that they have overcharged when they enter the payment stage and want to cancel the additional service manually, the system will display that the trip is repeated and automatically jump to the original order. Can these unintentionally purchased products and services be cancelled? To this end, the reporter telephoned Tongcheng Yilong customer service.

　　　　　　 Tongcheng yilong customer service: "yes, we can help you return it here. Please show me the mobile phone number you booked, and I will check it for you."

　　　　　　 For some time, through consumer complaints and industry rectification, the after-sales service of some travel apps has been adjusted and improved accordingly. However, it is also the general mentality of many consumers to tolerate giving up the choice of overcharge because of the small amount and fear of complaints.

　　　　　　 Consumer: "I think if it’s only a few tens of dollars, maybe we won’t handle it too much, unless the change is particularly great."

　　　　　　 Then, do other third-party ticketing platforms also have the phenomenon of bundled sales? The reporter booked a second-class high-speed rail ticket from Shanghai Hongqiao to Beijing South Railway Station on Mama Donkey APP, and the ticket’s face price was 553 yuan. When the reporter clicked Submit Order, the total order amount was 623 yuan. In the process, the reporter did not check any additional items. After clicking on the details, the reporter found that there is a 50-yuan "VIP Lightspeed Ticket Package", which includes the exclusive fast return and change service, SMS reminder service, and the so-called gift coupons for 10 yuan train tickets and 25 yuan pick-up and drop-off. These extra "packages" are all checked by default. If the consumer doesn’t take the initiative to cancel, the extra fee will be paid together with the ticket money.

　　　　　　 Subsequently, the reporter chose the second-class high-speed train ticket from Shanghai Hongqiao to Beijing South Railway Station on the Tuniu APP on the same day, and found that there was something fishy. After the fare of 553 yuan, the 30 yuan pick-up station coupon was added in small font.

　　　　　　 Through a series of experiments, the reporter found that on online travel apps such as Tongcheng Yilong, Mama Donkey, Tuniu, etc., there are widespread phenomena of bundled consumption of train tickets and default check. When the order is finally paid, there will be more expenses such as quick ticketing, insurance service, hotel coupons and car rental vouchers for no reason. For these expenses, the platform has not made obvious consumption tips.

　　　　　　 How do consumers deal with the "default tying" situation that is common in third-party ticketing platforms? The reporter randomly selected some Beijing citizens.

　　　　　　 Consumer: "One is insurance, the other is a refund, and the other one seems to be the one who booked the ticket, so it can be expedited. If you are insured, you may be excusable. If you want that, you will speed up the booking. I feel quite deficient. You have as many tickets as you originally had, right? "

　　　　　　 Consumer: "I met it when I ordered it from those softwares, but I usually take a look at it. You can check it." It is generally cancelled, but it may be accidentally paid when you are not paying attention. "

　　　　　　 The paid service options of some ticketing platforms are deeply hidden, and consumers are easily "routined" and spend money inexplicably.

　　　　　　 Consumer: "It should have a hint. Some people may say that if they don’t need it, they will just order it. If there is no hint, it will be inexplicable. Sometimes they may not find it for a long time."

　　　　　　 Consumer: "We young people have extra tens of dollars for this, we can find it in time and cancel it, but for many middle-aged and elderly people, they may not find it, and then they will be cheated of these tens of dollars."

　　　　　　 Consumer: "If it is really not checked, we will buy it, then maybe I will call customer service, talk to him about it, ask him to give me an explanation, or return the part we don’t need."

　　　　　　 [Expert opinion] Default tying infringes on consumers’ rights and interests.

　　　　　　 In this regard, legal experts made it clear that it is illegal for businesses to default to tying to infringe on consumers’ rights and interests. Many laws, such as the Anti-Monopoly Law, the Anti-Unfair Competition Law, the Consumer Rights Protection Law and the E-Commerce Law to be implemented next year, have clearly regulated the tying behavior of merchants.

　　　　　　 Taking the Law on the Protection of Consumer Rights and Interests as an example, Article 8 stipulates that consumers have the right to know the real situation of the goods they buy or use or the services they receive; Article 9 stipulates that consumers have the right to choose their own goods or services. This also means that consumers have the right to choose to accept or refuse to buy any goods, and they should clearly know the products or services they want to buy when placing an order, rather than being misled by the merchants.

　　　　　　 Jian Chen, director of the Legal and Theoretical Research Department of China Consumers Association, said: "Article 26 of the Consumer Law has special provisions on format clauses, which clearly inform consumers of some related information, such as the price of goods and services, and some important information related to consumers’ interests. Moreover, there is also a provision in it, which means that when you use the format clause, you can’t use technical means to hide and force the transaction at the same time. "

　　　　　　 Zhu Wei, deputy director of the Communication Law Research Center of China University of Political Science and Law, said: "The E-commerce Law that has just been passed and will be implemented soon has clear provisions on the prohibition of tying. Tying does not mean that it is 100% impossible. The prerequisite is that consumers must be fully informed of the existence of tying behavior, and then consumers should be given a free choice on the basis of respecting their free choice and fair trade rights."

　　　　　　 In fact, it is understandable to charge a certain fee for providing value-added services. As long as consumers agree, tying is sometimes a more convenient way to buy. However, experts said that if the merchants use the smoke screen method to muddle through and set the default consent option for consumption, so that consumers unconsciously spend money, it will infringe on consumers’ right to know and free choice, which is actually an extremely short-sighted marketing behavior.

　　　　　　 During the interview, the reporter learned that many consumers have long been wary of the bundling and tying routines of online travel platforms.

　　　　　　 Experts remind that if consumers choose a third-party platform to purchase tickets, they must pay more attention, check it many times, and don’t click on payment easily. If you buy unnecessary services and products, you can keep the corresponding evidence through screenshots and negotiate with the merchants. If negotiation fails, you can complain to the market supervision department or consumer rights protection organization, or you can directly bring a lawsuit in court.

　　　　　　 In order to protect the legitimate rights and interests of the vast number of passengers, the website of China Railway Customer Service Center 12306 made an announcement on its official website as early as 2015, reminding passengers to directly log on to the website of 12306 or the mobile client of 12306 to purchase tickets, and not to purchase tickets through third-party purchasing websites and mobile clients, so as to avoid the inability to refund or change tickets online because the purchasing party fraudulently uses other people’s information, which will affect travel; Remind passengers not to provide personal information to third-party websites and mobile phone clients to avoid risks caused by personal information disclosure.

fiveOn February 12th, Pinduoduo Billion Subsidy Channel showed that the price of 128GB of 16Pro dropped to 5998 yuan, and the price after grabbing the coupons was as low as 5498 yuan, which is the lowest price of iPhone 16 Pro so far.

This price can also be sold to recyclers at a higher price. Zhiyu, a blogger doing recycling business, said that the recycling price of 128GB iPhone 16 Pro is 5,800 yuan.

It is worth mentioning that due to the listing of the new iPhone16, the price of the iPhone15 continues to fall. According to authoritative scientific and technological media reports, iPhone15 is being auctioned off [】 In the latest event, the transaction price was only 239 yuan, which set a new low since the aircraft went on the market. I visited the auction house in official website.Get the latest details!

It is understood that compared with previous years, the promotion of Apple in this year’s 618 Shopping Festival is obviously stronger, and the price of JD.COM and other platform countries is 5499 yuan. Senior analyst of Canalys, a research institute, pointed out that the first half of the year was Apple’s off-season, and the sales situation in the first quarter was not ideal. It is expected that the challenge in the second quarter will be even greater.

Compared with last year, Apple’s sales volume declined this year. At present, there are some sales pressures, so Apple began to "reduce the price and change the quantity". From Apple’s point of view, there will still be sales in the short term, but in the medium and long term, its downward trend is still difficult to ease for the time being.

In the core configuration, the screen of iPhone 16 Pro is increased from 6.1 inches to 6.3 inches, equipped with A18 Pro chip, 8GB of memory, supporting Apple intelligence, 48 million AI three-shot, taking ultra-high resolution ProRAW and HEIF photos, supporting autofocus and supporting 5 times optical zoom.

And the iPhone 16 Pro is equipped with a dedicated camera button with tactile feedback function. This is currently Apple’s most powerful Pro model. Compared with the starting price, the iPhone 16 Pro with 5498 yuan is more competitive.

appleiPhone15(Licensed goods)
[Reference price] 5288 yuan
[Transaction price] 239 yuan

[e-commerce platform] Paiyide
[Event Website]

　　Today is the seventh "5.30 Science and Technology Workers’ Day", and the China Association for Science and Technology officially announced the list of the third national innovation first prize. The research team of pharmacokinetics and drug conversion of China Pharmaceutical University, led by China Academy of Engineering and Professor Wang Guangji of China Pharmaceutical University, won the medal of "National Innovation First Prize".

　　In mid-May, the reporter visited Academician Wang Guangji and his team in Jiangsu Key Laboratory of Pharmacokinetics of China Pharmaceutical University. The first impression that Academician Wang Guangji gave reporters was that he spoke slowly, humbly and kindly. In the interview, the reporter found that Academician Wang Guangji still used a non-smart phone that could only make calls and send text messages more than a decade ago. "I hope to study science better and not be disturbed too much by the outside world." Academician Wang Guangji said.

　　Over the years, Academician Wang Guangji’s team has focused on the frontier of biomedicine, breaking through the "stuck neck" problems in the biomedical field, such as the discovery of many new drug targets, the research and development and transformation of innovative biopharmaceuticals for precision treatment, cell drugs and high-end preparations.

　　On the wall of the team lab, there is a saying that success comes from strict self-management and perseverance.

　　Research team of pharmacokinetics and drug conversion for precision treatment in China Pharmaceutical University

　　Devote oneself to pharmacokinetics

　　Strive to break the "black box effect" of traditional Chinese medicine

　　What is pharmacokinetics? Wang Guangji replied that pharmacokinetics mainly studies the absorption, distribution, metabolism and excretion of drugs by the human body. In the past, people took a certain medicine, but they probably didn’t know how the medicine affected the body and made us get better or recover, which was similar to a "black box". Pharmacokinetics can make this "black box" transparent and change the efficacy of drugs from qualitative to quantitative. After taking a pill, you can observe when and what concentration the drug is in the human body, when it has the greatest efficacy, and when the drug has no effect and needs to be supplemented. Therefore, it is essential to establish a high-level preclinical pharmacokinetic technology platform for the creation and research of new drugs.

　　Wang Guangji became attached to pharmacokinetics more than 40 years ago. In the 1980s, the pharmacokinetics of drugs in China just started, and its research involved complex mathematical problems, which fascinated the young Wang Guangji and prompted him to choose this research field and go abroad for further study.

　　In 1995, Xia Lin, then Vice President of China Pharmaceutical University, invited Wang Guangji to work in China. He declined the invitation of foreign tutors and decided to return to China to devote himself to the discipline construction and scientific research of pharmacokinetics in the motherland. In Wang Guangji’s mind, there has always been a firm belief that scientists are persistent in science, but more persistent in the feelings of home and country. No matter how high your personal achievements are, you can’t compare with the joy of seeing the vigorous development of pharmacy in your motherland.

　　Today, after years of hard work, Academician Wang Guangji’s team has overcome a number of "stuck neck" technologies, and the internationally advanced preclinical pharmacokinetic technology platform established by the team has become an important support system for innovative drug research and development in China; Take the lead in expanding the pharmacokinetics of traditional Chinese medicine from single component to multi-component research; From macroscopic plasma to microscopic cells, the detection problem of drug concentration in cells is solved technically, and a new mathematical model is established to help clinical precise treatment. "Through the cross-integration of disciplines, we can see the process of drug metabolism in cells and how to enter the nucleus through the cell wall and how to distribute it after entering the cell. In this way, it can better guide clinical combined medication and precise treatment. " Wang Guangji explained.

　　It is precisely because the drug metabolism has become considerable and sensible that Wang Guangji’s team has also solved the problem that traditional Chinese medicine has formed a "black box" in the human body for many years. "In view of the difficulties in the detection of complex components of traditional Chinese medicine, the identification of metabolic pathways and the analysis of material basis, we have established an international advanced longitudinal research system on pharmacokinetics of traditional Chinese medicine, which not only reveals the role of multi-target and overall regulation of traditional Chinese medicine, but also explains the major scientific problems of treating both the symptoms and root causes of traditional Chinese medicine and promotes the modernization of traditional Chinese medicine." Wang Guangji said.

　　Juli original technology research

　　Help China’s biomedicine to "lead"

　　Innovation is the core competitiveness of biomedical industry. In recent years, drug research and development is developing from small molecule drugs, targeted drugs and antibody drugs to cell drugs. China’s biomedical industry is striding from "running with" to "running with" and then to "leading".

　　"Finding brand-new targets and developing class 1 innovative drugs" is the key to "leading the way" and the most difficult "hard bone" in pharmaceutical field. "Doing basic research is the key. Only when we lay a good foundation and walk ahead can we find more targets and produce more’ China drugs’. " Wang Guangji told reporters.

　　Scientific research comes from clinical needs, and also to better solve the problems of clinical needs. In 2019, Sun Lingyun’s team of Nanjing Gulou Hospital won the second prize of national technological invention for "Research on key technological innovation and clinical application of allogeneic mesenchymal stem cells in the treatment of refractory lupus erythematosus". In order to benefit more patients, Professor Sun Lingyun, then vice president of Gulou Hospital, sought the collaboration of Academician Wang Guangji, hoping to turn this medical technology into stem cell medicine, making the treatment safer, more effective and more controllable in quality. After three years’ efforts, this stem cell product independently developed by China for the treatment of lupus nephritis has entered the II clinical stage.

　　Academician Wang Guangji is doing experiments with students.

　　"In the past, drugs were constantly metabolized after being injected into the body and could not be regenerated, but when living cells were injected into the body as drugs, they could proliferate in the human body and then go where they needed to go. Therefore, cell drugs will have unique effects in treating immune imbalance and tissue repair. " Wang Guangji told reporters, "If chemical drugs and traditional Chinese medicine are the first generation drugs and vaccine biotechnology drugs are the second generation drugs, then cell drugs belong to the third generation drugs." Wang Guangji explained, "This is a revolution in clinical medicine with broad prospects. For the biomedical industry, this is a brand new track, which is worthy of our innovation. "

　　From a medical technology to the research and development of stem cell products, based on a mature technical system. A few years ago, Wang Guangji’s team developed a research technology system on pharmacokinetics and drug-forming properties of living cell drugs to meet the great demand of rapid development and drug-forming transformation of cell drugs such as CAR-T and stem cells, which can reveal the relationship between the fate and efficacy of living cell drugs in vivo and help to formulate clinical precise treatment plans.

　　Inherit the essence, keep the integrity and innovate. Traditional Chinese medicine is a treasure of our country. How to make traditional Chinese medicine better modernized is a subject before many pharmaceutical experts. "Traditional Chinese medicine is difficult to be recognized by the international medical academic community because of the problems of clear efficacy and unclear material basis, which seriously restricts the modernization of traditional Chinese medicine and its entry into the international medical market." Wang Guangji said.

　　In view of the low oral utilization rate of most traditional Chinese medicines and the accumulation of a large number of traditional Chinese medicine components in the intestine, Wang Guangji’s team put forward the theory of "symbiotic metabolism of traditional Chinese medicine-flora-host", revealing that traditional Chinese medicine components can play a remote regulatory role through "heart axis" and "brain-intestine axis". "Based on this research model, we found inspiration from a medicinal material in Compendium of Materia Medica, extracted new compounds, and discovered a new drug ZH01 which can quickly relieve depression. At present, we have applied for a patent." Wang Guangji introduced.

　　Academician Wang Guangji

　　Both wisdom and ingenuity

　　The essence of scientific research lies in the treatment of diseases by drugs.

　　The medical way is helpful to the world, and the fine industry is rich. In Wang Guangji’s view, pharmacists should not only have the kindness of doctors, but also have wisdom, ingenuity and harmony-

　　Wisdom, emphasizing the ability to put forward innovative ideas and methods, as well as unique scientific insights, will eventually bring new understanding and breakthroughs to China’s pharmaceutical industry, and do useful scientific research that can solve clinical problems and land; Ingenuity requires Excellence in experimental design, data analysis and interpretation of results, pursuing excellent scientific research quality and pushing scientific research to a higher level. Wisdom and ingenuity complement each other and together constitute the core quality of outstanding scientific researchers. Harmony, that is, cooperation, should maintain a humble attitude, actively communicate and cooperate with others, and draw inspiration and inspiration from different angles and ways of thinking. The most important thing is to persist in loving science, keep the passion and pursuit of scientific research, drive yourself forward in the field of scientific research with wisdom and ingenuity, and make contributions to scientific progress and social development.

　　In the team of Academician Wang Guangji, there are leading talents such as academicians, Changjiang scholars and national Jie Qing, and more and more "post-90 s" and "post-00 s" have joined. In the eyes of students, Wang Guangji is a strict teacher and a kind teacher.

　　"The team pays attention to bringing the old with the new, which can not only help young people establish a good research direction in the early stage of their scientific research career, but also set an example for them in scientific research. We not only pay attention to the communication and cooperation within the team, but also encourage and support interdisciplinary scientific research cooperation and exchanges with other teams to provide more learning platforms and development opportunities for young people. " Wang Guangji said that scientific research must not be done behind closed doors. Don’t just work hard, you must learn to look up and ask for directions. Pharmacy itself is an interdisciplinary science that combines medicine, chemistry and biology, and teamwork has become the key to promote interdisciplinary research.

　　Research team of pharmacokinetics and drug conversion for precision treatment in China Pharmaceutical University

　　Pharmacy is a long-time-consuming, high-input and high-risk industry because it has its particularity because it undertakes the "weight of life". The research and development of a new drug often takes about 15 years and costs 2 billion dollars, and less than 10% of the products that finally enter the clinic can be approved for marketing. This means that pharmaceutical research must endure loneliness and setbacks and always pursue Excellence.

　　"I often tell my classmates that to learn, we must constantly improve our insight and concentration on problems. This requires extensive literature reading and lifelong learning mode, and at the same time pays attention to the cultivation of practice and experimental skills. Don’t be afraid of failure, find the right goal and keep going, even if the experiment fails 100 times, it is enough for the ultimate success! As long as you are willing to study hard and be willing to work hard, you will always solve the problem and have a bright future. "

　　This year, Academician Wang Guangji is just 70 years old. From 1977 to now, he devoted himself to the study of pharmacokinetics. At that time, the young scallion had arrived in seventy years of age, and his hair had turned white. But he didn’t change his mind.

　　At the end of the interview, Wang Guangji told the reporter about an experience when he was studying: "Pharmacokinetics often takes a long time to collect blood samples continuously, and the experiment is very tiring. When I was young at the University of Queensland in Australia, I stayed in the laboratory for 48 hours. When the school security guard saw a light in the window to check, he was surprised and asked, why are you still here? "

　　The simple words of security guard are still imprinted on Academician Wang Guangji’s mind. Why are you still here? "It is also the motto of our team-success comes from strict self-management and perseverance." Academician Wang Guangji said. Up to now, his daily working hours are still from 8: 00 am to 12: 00 pm, which is not inferior to the young people in the team. "Scientific research should be carried out and the results should be for the people. Only by truly solving problems at the new drug development terminal and getting safe and effective results in clinical patients is the ultimate meaning of scientific research. "

　　Xinhua Daily Meeting Point reporter Ye Zhen

　　Correspondent Jiang Chentu/Cui Jiayue