Cell: Using AI Agents to Drive Biomedical Discovery

Compilation Shu Wang Cong

Editor: Wang Duoyu

Typesetting Shu Shui Chengwen

The long-term vision for artificial intelligence (AI) is to develop AI systems that can make major scientific discoveries, learn autonomously, and acquire knowledge autonomously.

虽然“AI 科学家”(AI scientist)这一概念还只是一种理想化的愿景,但基于智能体(agent)的AI技术的发展,为开发能够进行对话、具备反思学习和推理能力的AI智能体(AI agent)铺平了道路,这些AI智能体能够协调大型语言模型(LLM)、机器学习(ML)工具、实验平台,甚至是它们的组合。

近日,哈佛大学医学院 Marinka Zitnik实验室(高尚华博士为第一作者)在 Cell 期刊发表了题为:Empowering biomedical discovery with AI agents 的文章,系统介绍了利用 AI 智能体(AI agent)推动生物医学发现。

该文章提出了这样一个观点——“AI 科学家”可以被由人类、大语言模型、机器学习模型及其他工具(例如实验平台)组成的复合AI系统所支持的 AI 智能体(AI agent)所实现。

我们将“AI 科学家”设想为具备批判性学习和推理能力的系统,它们能够通过协作智能体整合 AI 模型和生物医学工具,并与实验平台相结合,从而为生物医学研究提供助力。

生物医学 AI 智能体不是将人类排除在发现过程之外,而是将人类的创造力和专业知识与 AI 分析大量数据、探索假设空间和执行重复性任务的能力相结合。AI 智能体将能够熟练完成各种任务,规划发现工作流程并进行自我评估,以识别并解决其知识中的差距。这些智能体使用大语言模型(LLM)和生成式模型来实现结构化记忆以进行持续学习,并使用机器学习工具将科学知识、生物学原理和理论融入其中。AI 智能体可以影响从虚拟细胞模拟、可编程的表型控制到细胞回路设计以及开发新疗法等各个领域。

The first author, Dr. Gao Shanghua, received his doctorate from Nankai University and is now a postdoctoral researcher at Harvard Medical School

The complexity of biology requires the flexibility to break down complex problems into executable tasks. AI agents can break down problems into manageable sub-tasks, which are then solved by AI agents with specific functions and integrate scientific knowledge. In the near future, AI agents can accelerate the discovery process by making workflows faster and more resource-efficient.

Leveraging AI agents to advance biomedical research

The continuous development and application of data-driven models

AI agents in the biomedical field – from LLM-based AI agents to multi-agent systems that integrate AI models, tools, and physical devices

Level of autonomy of AI agents

Cases of autonomy levels for AI agents in genetics, cell biology, and chemical biology

Core terms of machine learning

Key modules in AI agents: perception, interaction, reasoning, and memory modules

Components of a biomedical AI agent

The challenges of AI agents in biomedical discovery

AI agents can improve the efficiency of routine tasks, automate repetitive processes, and analyze large datasets to outperform current human-driven efforts in scale and accuracy. This automation allows for continuous, high-throughput research that human researchers cannot conduct individually at the same scale or speed.

Looking to the future, AI agents can provide insights beyond what traditional machine learning can achieve by making predictions across temporal and spatial scales before obtaining experimental measurements at both temporal and spatial scales. Ultimately, AI agents may help uncover new patterns of behavior in biological systems.

Original link:

https://www.cell.com/cell/fulltext/S0092-8674 (24) 01070-5

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Keynote Speech by the Chairman of the Supreme Leader at the Opening Ceremony of the 2017 Annual Meeting of the World Economic Forum (full text)

  Xinhua News Agency, Davos, Switzerland, January 17th-The Supreme Leader of president attended the opening ceremony of the 2017 annual meeting of the World Economic Forum on January 17th and delivered a keynote speech entitled "Sharing the responsibility of the times and promoting global development together". The full text of the speech is as follows:

Sharing the responsibility of the times and promoting global development

— — Keynote speech at the opening ceremony of the 2017 annual meeting of the World Economic Forum

(Davos, January 17, 2017)

Chairman People’s Republic of China (PRC), Supreme Leader

  Dear President Leuther Harder and Mr. Hausen,

  Distinguished heads of state, heads of government, deputy heads of state and their wives,

  Dear heads of international organizations,

  Dear President Schwab and his wife,

  Ladies and gentlemen, friends,

  I am very happy to come to beautiful Davos. Although Davos is only a small town in the Alps, it is an important window to observe the world economy. Everyone gathered here from all directions, and all kinds of ideas collided with sparks of wisdom, and achieved high output with less input. I think this phenomenon can be called "Schwab economics".

  "This is the best time, but also the worst time", British writer Dickens once described the world after the industrial revolution. Today, we also live in a contradictory world. On the one hand, material wealth is accumulating, scientific and technological progress is changing with each passing day, and human civilization has developed to the highest level in history. On the other hand, regional conflicts occur frequently, and global challenges such as terrorism and refugee flows are one after another. Poverty, unemployment and income gap are widening, and the uncertainty facing the world is rising.

  In this regard, many people are confused. What happened to the world?

  To solve this puzzle, we must first find the root of the problem. There is a view that the world chaos is attributed to economic globalization. Economic globalization was once regarded as the cave of Alibaba, and now it is regarded as Pandora’s box by many people. The international community has held extensive discussions around the issue of economic globalization.

  Today, I want to talk about my views on the world economy from the perspective of economic globalization.

  What I want to say is that many problems that plague the world are not caused by economic globalization. For example, in the past few years, the tide of refugees from the Middle East and North Africa has affected the whole world, millions of people have been displaced, and even many young children have been buried in the sea on the way, which makes us sad. The causes of this problem are wars, conflicts and regional turmoil. The way to solve this problem is to seek peace, promote reconciliation and restore stability. For another example, the international financial crisis is not the inevitable product of the development of economic globalization, but the result of excessive profit-seeking of financial capital and serious lack of financial supervision. Simply blaming the problems that plague the world on economic globalization is neither in line with the facts nor helpful to solve the problems.

  Historically, economic globalization is the objective requirement of the development of social productive forces and the inevitable result of scientific and technological progress, and it is not artificially created by any person or country. Economic globalization has provided a strong impetus for world economic growth and promoted the flow of goods and capital, the progress of science and technology and civilization, and people-to-people exchanges among countries.

  Of course, we also have to admit that economic globalization is a "double-edged sword". When the world economy is in a downturn, the "cake" of the global economy is not easy to get bigger or even smaller, and the contradiction between growth and distribution, capital and labor, efficiency and fairness will become more prominent, and both developed and developing countries will feel the pressure and impact. The voice of anti-globalization reflects the deficiency of the process of economic globalization, which deserves our attention and deep thinking.

  "Sweet melons are bitter, and beautiful dates are thorns." Philosophically speaking, there is no perfect thing in the world. It is not comprehensive to regard it as perfect because it has advantages, and it is not comprehensive to regard it as useless because it has disadvantages. Economic globalization has indeed brought new problems, but we can’t kill it with a stick, but we should adapt to and guide it, eliminate its negative effects and make it better benefit every country and nation.

  At that time, China had misgivings about economic globalization and had misgivings about joining the World Trade Organization. However, we believe that integration into the world economy is the historical direction. If China wants to develop its economy, it must dare to swim in the sea of Wang Yang in the world market. If it never dares to go to the sea to see the world, it will drown in the sea one day. Therefore, China bravely entered the world market. In this process, we choked over water, encountered whirlpools and encountered storms, but we learned to swim in swimming. This is the right strategic choice.

  The sea of the world economy, whether you want it or not, is there and you can’t avoid it. It is impossible to artificially cut off the capital flow, technology flow, product flow, industrial flow and personnel flow of various countries’ economies, and let the sea of the world economy retreat to isolated small lakes and rivers, which is also inconsistent with the historical trend.

  Human history tells us that it is not terrible to have problems. What is terrible is that we dare not face the problems directly and cannot find a way to solve them. Facing the opportunities and challenges brought by economic globalization, the correct choice is to make full use of all opportunities, cooperate with all challenges, and guide the direction of economic globalization.

  At the end of last year, I proposed at the informal meeting of APEC leaders that the process of economic globalization should be more dynamic, inclusive and sustainable. We should take the initiative and manage appropriately, so as to release more positive effects of economic globalization and realize the rebalancing of the process of economic globalization; We should conform to the general trend, combine the national conditions and correctly choose the path and rhythm of integrating into economic globalization; We should stress efficiency and fairness, so that different countries, different classes and different people can share the benefits of economic globalization. This is the responsibility of the leaders of our time, and it is also the expectation of people from all over the world.

  Ladies and gentlemen, friends!

  At present, the most urgent task is to lead the world economy out of the predicament. The world economy has been in a long-term downturn, and the gap between the rich and the poor and the gap between the north and the south has become more prominent. The root cause is that the three prominent contradictions in the economic field have not been effectively solved.

  First, the global growth momentum is insufficient to support the sustained and steady growth of the world economy. The growth rate of the world economy is at the lowest level in seven years, and the growth rate of global trade continues to be lower than the economic growth rate. Short-term policy stimulus is not effective, and deep-seated structural reforms are still being promoted. The world economy is in the shift period of kinetic energy conversion, and the pulling effect of traditional growth engines on the economy is weakened. Although new technologies such as artificial intelligence and 3D printing are constantly emerging, new economic growth points have not yet formed. The world economy has still failed to open up a new path.

  Second, global economic governance is lagging behind and it is difficult to adapt to the new changes in the world economy. Not long ago, Ms. Lagarde told me that the contribution rate of emerging market countries and developing countries to global economic growth has reached 80%. In the past few decades, the international economic power has undergone profound changes, but the global governance system has failed to reflect the new pattern, which is not representative and inclusive enough. The global industrial layout is constantly adjusting, and new industrial chains, value chains and supply chains are increasingly formed. However, trade and investment rules have failed to keep up with the new situation, and the mechanism is closed and the rules are fragmented. The global financial market needs to strengthen its ability to resist risks, but the global financial governance mechanism has failed to meet the new demand, and it is difficult to effectively solve the problems such as frequent turmoil in the international financial market and the accumulation of asset bubbles.

  Third, the global development is unbalanced and it is difficult to meet people’s expectations for a better life. In his book The Fourth Industrial Revolution, Mr. Schwab wrote that the fourth industrial revolution will have an extremely extensive and far-reaching impact, including increasing inequality, especially the gap between capital return and labor return. The wealth of the richest 1% population in the world exceeds the sum of the wealth of the remaining 99% population, and the unequal income distribution and unbalanced development space are worrying. More than 700 million people in the world still live in extreme poverty. For many families, having a warm house, enough food and a stable job is still a luxury. This is the biggest challenge facing the world today, and it is also an important reason for social unrest in some countries.

  These problems reflect that there are problems that must be solved in the current world economic growth, governance and development model. Du Nan, the founder of the International Red Cross, said: "The real enemy is not our neighbors, but hunger, poverty, ignorance, superstition and prejudice." We should not only have the wisdom to analyze problems, but also have the courage to take action.

  First, adhere to the drive of innovation and create a dynamic growth model. The fundamental problem facing the world economy is the lack of growth momentum. Innovation is the first driving force for development. Compared with previous industrial revolutions, the fourth industrial revolution unfolded at an exponential but nonlinear speed. We must find a way out in innovation. Only by daring to innovate and change can we break through the bottleneck of world economic growth and development.

  The G20 leaders reached an important consensus at the Hangzhou Summit, and they should take innovation as an important starting point to tap new impetus for economic growth of countries and the world. We should innovate the concept of development, go beyond the debate about whether fiscal stimulus is more or monetary easing is more, and establish the idea of treating both the symptoms and root causes and comprehensive policies. We should innovate policy means, promote structural reforms, create space for growth and increase stamina. We should innovate the growth mode, grasp the opportunities brought by the new round of industrial revolution and digital economy, not only deal with the challenges brought by climate change and aging population, but also resolve the impact of informationization and automation on employment, and pay attention to creating new employment opportunities in the process of cultivating new industries, new formats and new models, so that people of all countries can regain their confidence and hope.

  Second, adhere to synergy and create an open and win-win cooperation model. Human beings have become a community of destiny in which you have me and I have you. Their interests are highly integrated and interdependent. Every country has the right to development, and at the same time, it should consider its own interests at a broader level, not at the expense of the interests of other countries.

  We must unswervingly develop an open world economy, share opportunities and interests in opening up and achieve mutual benefit and win-win results. You can’t retreat to the harbor as soon as you encounter a storm, it will never reach the other side. We must make great efforts to develop global connectivity, so that all countries in the world can achieve coordinated growth and move towards common prosperity. We must unswervingly develop global free trade and investment, promote the liberalization and facilitation of trade and investment in the process of opening up, and take a clear-cut stand against protectionism. Protectionism is like shutting yourself in a dark room. It seems to have escaped the wind and rain, but it also isolates the sun and the air. The result of a trade war can only be mutual loss.

  Third, keep pace with the times and create a fair and reasonable governance model. Xiao Zhi governs affairs, and great wisdom governs the system. The urgency of the reform of the global economic governance system is becoming more and more prominent, and the voice of the international community is getting higher and higher. Only when the global governance system adapts to the new requirements of the international economic structure can it provide a strong guarantee for the global economy.

  All countries, big or small, strong or weak, rich or poor, are equal members of the international community and should participate in decision-making, enjoy rights and fulfill obligations on an equal footing. It is necessary to give emerging market countries and developing countries more representation and voice. In 2010, the IMF’s quota reform program has come into effect, and this momentum should be maintained. We must adhere to multilateralism and safeguard the authority and effectiveness of the multilateral system. To keep promises and abide by rules, you can’t choose or choose according to your own wishes. The Paris Agreement is in line with the general direction of global development, and the results are hard-won. We should stick to it together and not give up lightly. This is our responsibility to future generations!

  Fourth, adhere to fairness and tolerance and create a balanced and inclusive development model. "The trip to the avenue is also the world’s public." The purpose of development is to benefit the people. To make development more balanced, to make development opportunities more equal, and to share the fruits of development, it is necessary to improve the development concept and model and enhance the fairness, effectiveness and synergy of development.

  We should advocate the social atmosphere of diligence, frugality and hard work, so that all people’s labor achievements can be respected. Efforts should be made to solve problems such as poverty, unemployment and widening income gap, take care of the concerns of vulnerable groups and promote social fairness and justice. We should protect the ecological environment, promote the coordinated development of economy, society and environment, and realize the harmony between man and nature and between man and society. It is necessary to implement the United Nations 2030 Agenda for Sustainable Development and achieve balanced development on a global scale.

  "If you do what you do, you will be invincible; What the wisdom of all people does is nothing. " As long as we firmly establish the sense of community of human destiny, work together, share responsibility, help each other in the same boat and tide over difficulties together, we will certainly be able to make the world better and people happier.

  Ladies and gentlemen, friends!

  After 38 years of reform and opening up, China has become the second largest economy in the world. The road determines fate. The key to the development of China lies in that the people of China, under the leadership of the Communist Party of China, have embarked on a development path suitable for China’s national conditions.

  This is a road established from the national conditions of our country. China, based on its own national conditions and practice, draws wisdom from Chinese civilization, absorbs the strengths of eastern and western schools, sticks to it without being rigid, draws lessons from it without copying it, and forms its own development path through constant exploration. All roads lead to Rome. No one should regard their own development path as a statue, let alone impose their own development path on others.

  This is a road that puts people’s interests first. China adheres to the people-centered development thought, taking improving people’s lives and enhancing people’s well-being as the starting point and the end result, seeking development impetus among the people, relying on the people to promote development, and making development benefit the people. China adheres to the goal of common prosperity, vigorously promotes the cause of poverty reduction, helps more than 700 million people get rid of poverty, and is making rapid progress towards the goal of building a well-off society in an all-round way.

  This is a road of reform and innovation. China persists in solving the difficulties and challenges encountered in its progress through reform, dares to gnaw at hard bones and wade into dangerous beaches, dares to break down institutional and institutional obstacles that hinder development, and constantly liberates and develops social productive forces and enhances social vitality. In the past four years, we have launched more than 1,200 reform measures on the basis of continuous reform in the previous 30 years, which has injected a strong impetus into the development of China.

  This is a road to seek common development in opening up. China adheres to the basic national policy of opening to the outside world, pursues a win-win opening strategy, constantly enhances the internal and external linkage of development, and benefits more other countries and people while realizing its own development.

  China has made great achievements in its development, and the people’s lives in China have been greatly improved, which is good for China and the world. China’s development achievements are the result of decades of hard work, blood and sweat by the people of Chinese. For thousands of years, the Chinese nation has been known for its hard work and hard work. The people of China know very well that there is no free lunch in the world. China is a big country with a population of more than 1.3 billion. If you want to develop, you have to work hard on your own, and you can’t rely on the gifts of others. No one in the world has such ability.

  Observing the development of China depends on what the people of China have gained and what the people of China have worked hard. It depends not only on what China has achieved, but also on what China has contributed to the world. This is a comprehensive view.

  From 1950 to 2016, despite its low level of long-term development and people’s living standards, China provided more than 400 billion yuan in foreign aid, implemented more than 5,000 foreign aid projects, including nearly 3,000 complete sets of projects, held more than 11,000 training courses, and trained more than 260,000 people of various types in China for developing countries. Since the reform and opening up, China has attracted more than 1.7 trillion US dollars of foreign investment and 1.2 trillion US dollars of foreign direct investment, which has made great contributions to the development of the world economy. Since the outbreak of the international financial crisis, the contribution rate of China’s economic growth to world economic growth has been above 30% annually. These figures are among the best in the world.

  From these figures, we can see that the development of China is an opportunity for the world, and China is a beneficiary and a contributor of economic globalization. China’s rapid economic growth has provided a sustained and powerful impetus to global economic stability and growth. The coordinated development of China and a large number of countries has made the global economic development more balanced. China’s great achievements in poverty reduction have made global economic growth more inclusive. China’s continuous reform and opening up has provided an important impetus for the development of an open world economy.

  The people of China are well aware of the hardships of achieving national prosperity and strength. They all praise the development achievements made by the people of other countries and wish them all the best. They all hope that their lives will get better and better, and they will not commit "red eye disease" or complain that others have gained great opportunities and rich returns from the development of China. The people of China welcome people from all countries to take the "express train" and "free ride" developed by China with open arms.

  Ladies and gentlemen, friends!

  Many people are paying attention to the economic development trend of China. China’s economic development has entered a new normal, and major changes are taking place in economic growth rate, economic development mode, economic structure and economic development momentum. However, the long-term positive fundamentals of China’s economy have not changed.

  In 2016, against the background of weak world economy, China’s economy is expected to grow by 6.7%, still in the forefront of the world. Now, the size of China’s economy can’t be compared with the past, and the kinetic energy of agglomeration can’t be reached by the past double-digit growth. China residents’ consumption and service industry have become the main driving forces of economic growth. In the first three quarters of 2016, the added value of tertiary industry accounted for 52.8% of GDP, and the contribution rate of domestic consumption to economic growth reached 71%. Residents’ income and employment have achieved steady growth, energy consumption per unit of GDP has continued to decline, and green development has achieved initial results.

  At present, China’s economy is facing certain downward pressure and many difficulties, such as the contradiction between overcapacity and upgrading of demand structure, the lack of endogenous motivation for economic growth, the accumulation of financial risks and the increase of difficulties in some areas. We believe that these are inevitable stage phenomena in the process of progress, and we are making great efforts to solve these problems and contradictions, and have continuously achieved positive results. Our firm determination to move forward will not waver. China is still the largest developing country in the world. China has a population of more than 1.3 billion, and its people’s living standard is not high, but it also means great development potential and space. Under the guidance of the development concept of innovation, coordination, green, openness and sharing, we will constantly adapt to, grasp and lead the new normal of China’s economic development, and make overall plans to stabilize growth, promote reform, adjust structure, benefit people’s livelihood and prevent risks, so as to promote China’s economy to maintain medium and high-speed growth and move towards the middle and high-end level.

  — — China will focus on improving the quality and efficiency of economic growth, change the mode of economic development around the main line of supply-side structural reform, optimize the economic structure, actively promote de-capacity, de-inventory, de-leverage, reduce costs and make up shortcomings, foster new growth momentum, develop advanced manufacturing industries, realize the upgrading of the real economy, implement the "internet plus" action plan in depth, expand effective demand, better meet people’s personalized and diversified needs, and better protect the ecological environment.

  — — China will continue to stimulate growth momentum and market vitality, intensify reforms in important areas and key links, make the market play a decisive role in resource allocation, hold the "bull’s nose" of innovation, promote the development strategy of innovation-driven development, promote the development of strategic emerging industries, focus on upgrading traditional industries with new technologies and new formats, and promote the development and growth of new kinetic energy and the rejuvenation of traditional kinetic energy.

  — — China will actively create a relaxed and orderly investment environment, relax foreign investment access, build a high-standard free trade pilot zone, strengthen property rights protection, promote fair competition, and make the China market more transparent and standardized. It is estimated that in the next five years, China will import 8 trillion US dollars of goods and absorb 600 billion US dollars of foreign investment, with a total foreign investment of 750 billion US dollars and 700 million outbound tourists. This will provide countries around the world with a broader market, more capital, richer products and more valuable opportunities for cooperation. For the industrial and commercial circles of all countries, the development of China is still an opportunity for everyone. The door of China is always open to the world and will not be closed. With the door open, the world can enter China and China can go to the world. We hope that the doors of all countries will also be open to China investors fairly.

  — — China will vigorously build a common development pattern of opening to the outside world, promote the construction of the Asia-Pacific Free Trade Area and the negotiation of regional comprehensive economic partnership agreements, and build a global network of free trade areas. China has always advocated building an open, transparent, mutually beneficial and win-win regional free trade arrangement, rather than engaging in exclusive and fragmented circles. China has no intention to enhance its trade competitiveness through RMB depreciation, let alone take the initiative to wage currency wars.

  More than three years ago, I proposed the Belt and Road Initiative. Over the past three years, more than 100 countries and international organizations have actively responded to support, and more than 40 countries and international organizations have signed cooperation agreements with China. The "circle of friends" of the Belt and Road Initiative is constantly expanding. China enterprises have invested more than 50 billion dollars in countries along the route, and a series of major projects have blossomed, which has promoted the economic development of various countries and created a large number of employment opportunities. It can be said that the Belt and Road Initiative came from China, but its effectiveness has benefited the world.

  In May this year, China will host the "One Belt, One Road" international cooperation summit forum in Beijing to discuss cooperation plans, build a cooperation platform, share cooperation achievements, find solutions to the current problems facing the world and regional economies, inject new energy into the coordinated development, and make the "One Belt, One Road" construction better benefit people of all countries.

  Ladies and gentlemen, friends!

  The development of world history tells us that there has never been a smooth road to the progress of human civilization, and human beings are advancing in the struggle against difficulties. No matter how difficult it is, it is impossible to stop the pace of human progress. When you encounter difficulties, don’t blame yourself, don’t blame others, don’t give up confidence, don’t shirk your responsibilities, but overcome them together. History is made by brave people. Let’s show confidence, take action and move forward hand in hand towards the future!

  Thank you all.

It’s been more than five years, but it’s back!

2025 Spring Festival File

Four films have been booked.

Did you find the point?

"Nezha’s Devil Children Naughting the Sea" is scheduled for New Year’s Day.

Successfully entered the most "brutal" schedule of the year-Spring Festival.

And behind this high-profile sequel

Xiangcheng corporation

Suzhou hongjing movie and television cultural communication co., ltd

(hereinafter referred to as "Red Whale Film and Television")

Once again played a vital role.

★ Ge Yi, the person in charge of the enterprise

As the animation director of "Nezha’s Devil Children Making a Sea".

★ The enterprise undertakes the main production tasks.

The total duration is over 20 minutes.

According to the official website of the State Film Bureau, the story outline of "Nezha’s Devil Children Naughting the Sea" is as follows: After the natural disaster, although the souls of Nezha and Ao Bing were saved, their bodies will soon be out of their wits. Taiyi real person intends to reshape the flesh of the two with seven-color lotus. However, there are many difficulties in the process of remolding the flesh. Where will the fate of Nezha and Ao Bing go?

Ne Zha, which was released in 2019, was deeply loved by the audience with its unique painting style and profound theme. In the end, the box office exceeded 5 billion, making it the number one animated film in China film history. With the perfect presentation of Ne Zha, the audience’s expectations for "The Devil’s Child in Nezha" are full, which also requires the film to be continuously upgraded in production and bring more shocking experiences to the audience.

According to the production team of Red Whale Film and Television, compared with the 400 special effects shots that participated in the production of Ne Zha, the company undertook the main production task, involving all the production processes of art, animation and special effects, with a total duration of over 20 minutes, and wonderful animation chapters, which condensed the team’s countless hard work and creativity day and night.

Ge Yi, the head of Red Whale Film and Television, served as the animation director of "Nezha’s Devil Children Making a Sea". Under his leadership, the team kept polishing the production, striving to carve every picture and every movement to the extreme, and went all out to present the most shocking and moving universe to the audience.

"Anime movies should have an immersive experience. In the production process, more attention should be paid to the use of colors, scene transformation and depth of field, so the control of details is stricter, from the details of an object to the creation of a scene. It needs to be fine enough." According to Ge Yi, the whole project company invested a total of 160 producers, and it took about 26 months to complete the work goal.

Since Red Whale Film and Television settled in Suzhou Xiangcheng High-speed Railway Xincheng Film and Television Animation Industrial Park in March 2017, it has made its mark in the field of film and television and game animation with its outstanding strength. Its creative team has successively created many explosive movies such as Ne Zha and Legend of Deification, and also carefully produced CG for large-scale games such as Yin and Yang Master, After Tomorrow and League of Legends, leaving high-quality word-of-mouth works for audiences in different fields.

"Nezha’s Devil Children Make a Sea"

File the first day of the lunar new year.

Looking forward to the "Nezha" box office.

Leading all the way and reaching new heights.

Remember to bring your family and friends.

Call for Nezha together!

Extended reading:

Ne Zha, the former film, was written and directed by jiaozi (formerly known as Yu Yang) and was released in Chinese mainland on July 26th, 2019. The story background of the film comes from the story of Nezha in the fairy tale "The Romance of the Gods", and based on this, it is adapted to portray Nezha as a "magic boy" in troubled times who has come into the world by mistake. The film tells a fantastic story about this character, although he was born as a magic, but he went against the sky.

After the release of Ne Zha, it caused a great response, and the box office word-of-mouth double harvest. Not only did it win the Golden Dragon Award, the Hundred Flowers Award Award and the Golden Rooster Award in China, but the box office finally exceeded 5 billion, making it the first animated film in China film history. Red Whale Film and Television actively participated in the production of the film. About 400 of the 1,800 realistic and delicate shots in the whole film came from enterprises, and most of them were time-consuming and difficult special effects shots, which contributed an important force to this phenomenal film.

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Original title: "More than 5 years, it can be counted back! 》

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Fulin village in Qijiang: the village is beautiful, the people are rich, the industry is prosperous, and the countryside is picturesque.

Workers in Fuliu Fruit and Vegetable Farm in Fulin Village are transplanting corn seedlings. Photo by Yan Ningbo

Workers in Fuliu Fruit and Vegetable Farm in Fulin Village are transplanting corn seedlings. Photo by Yan Ningbo

Fulin Village, Dongxi Town, Qijiang District, 5 kilometers away from Dongxichang Town, has 10 villagers’ groups under its jurisdiction, with a total of 3,245 people in 961 households. In recent years, Fulin Village, taking the construction of Hemei village as an opportunity, has made continuous efforts in promoting industrial revitalization, serving the construction of major projects, and promoting the improvement of human settlements for a long time.

Prosperous industry and increasing income of the masses

At present, it is spring ploughing and sowing. In Fuliu Fruit and Vegetable Farm in Fulin Village, we can see that in the well-regulated high-standard farmland, workers are helping seedlings, covering the soil and compacting … transplanting corn seedlings into the soil, and the fields are busy. Large tracts of newly transplanted corn seedlings are green and dripping, fluttering in the sun and showing infinite vitality.

"The farm mainly grows seasonal fruits and vegetables such as corn, jar beans, green beans, lettuce, spinach, cabbage and watermelon." Peng Zongqiang, the head of Fuliu Fruit and Vegetable Farm, worked outside for a few years and had some savings in his hand. In September 2022, he responded to the call of "returning to his hometown for development" and returned to Fulin Village to transfer 46.8 mu of land to start planting fruits and vegetables at the transfer price of 500 yuan/mu.

"At that time, these lands had been transformed into high-standard farmland, and tractor roads and irrigation canals were also repaired to farms." Peng Zongqiang said that the complete infrastructure has saved a lot of time and economic costs and greatly enhanced the confidence in development. With the strong support of Murakami, the farm was soon built and put into production.

In order to increase the output of fruits and vegetables and realize large-scale and standardized production, Peng Zongqiang’s fruit and vegetable farm cooperates with Chongqing Institute of Modern Agricultural Technology and Equipment. The research institute provides technical support for the farm in soil improvement, breeding and seedling raising, fertilizer application and pest control.

"Last year, when some vegetable markets were not very good, the gross income of the farm was more than 200,000 yuan." Peng Zongqiang said frankly.

After Peng Zongqiang’s fruit and vegetable farm settled in Fulin Village, it provided employment opportunities for more than 20 villagers around. Li Yixian, 60, is one of them. As a "long-term worker" in the fruit and vegetable farm, she is responsible for turning over the soil, raising seedlings, harvesting, etc. She walks through the fruit and vegetable farm every day, which is both busy and fulfilling. "I work here, I have something to do every day, and I have a fixed income of 1,600 yuan a month." Li Yixian said.

"Next, we will cooperate with the village to build greenhouses to further expand the scale, and at the same time build corridors to turn the farm into a modern farm integrating farming experience and leisure and sightseeing, so as to drive more villagers to get rich together." Peng Zongqiang said.

In Fulin Village, Peng Zongqiang is not a case. According to Zhao Fulong, the village’s first resident secretary, in recent years, the village has continuously improved its infrastructure, introduced owners and guided farmers, and vigorously developed more than 500 mu of fruit and vegetable industries such as pepper, radish, sorghum, rape, lotus root and watermelon according to local conditions. In 2023, it achieved sales income of more than 700,000 yuan, which effectively boosted villagers’ income, and at the same time, the village collectively earned more than 50,000 yuan. In addition, the village collective also established Chongqing Xiyu Construction Labor Service Co., Ltd. to undertake projects such as canals, fire pools and village-level highway maintenance, with an annual income of over 200,000 yuan.

Service projects promote development together.

In April, at the construction site of Fulin Reservoir Project in Fulin Village, excavators waved their long arms, engineering vehicles shuttled back and forth, and construction workers performed their duties … everywhere was a scene of intense construction.

"I come here every day to have a look, and I hope it will be repaired soon." Wu Yongwan, 60, lives nearby and visits the observation deck every day. In his words, "I haven’t seen it for decades. It’s beautiful."

As a key construction project at the municipal and district levels, the total estimated investment of Fulin Reservoir Construction Project is 749 million yuan, which is a medium-sized water conservancy project with the functions of agricultural irrigation and water supply for towns and towns, and comprehensive utilization of drinking water for rural people and livestock in irrigation areas. After the project is completed and put into use, it will meet the irrigation water demand of 16,000 rural residents, 69,200 town residents and 36,800 mu of farmland in 18 villages in Dongxi, Ganshui and Zhuantang.

In recent years, Fulin Village has focused on "good governance" and made great efforts to improve the effectiveness of rural governance in accordance with the working methods of "good organization, perfect mechanism, and good publicity by the masses" and "three goodness".

Good organization means giving full play to the exemplary role of the Party organization’s fighting fortress and the vanguard of party member, demonstrating and driving villagers to be the "protagonists" in rural construction, and actively participating in the construction and development of Fulin Village. Perfecting the mechanism means establishing and perfecting the "three ones", "three musts" working method and "three guarantees" gridding mechanism, so as to resolve various contradictions and disputes in the bud and achieve "everything has an explanation, everything has a landing, and everything has an echo". The masses promote kindness, that is, fully mobilize the enthusiasm of the masses to participate in self-government, set up a "Fulin Sunset Red" volunteer service team, carry out various volunteer services around the needs of villagers, and set up a village-level parliamentary hall to form a new pattern of rural governance that "everyone has something to discuss, talk about it together, and help together when it is difficult".

Renovating the environment and "refreshing" the village face

Fangfei in April, the spring is bright and warm. A winding country road runs from the head of Fulin village to the end of the village. Along the way, surrounded by clear water, birds singing and flowers fragrant, a patchwork of houses, a clean and bright small courtyard, and a unique wall painting … what a beautiful and peaceful picture of the countryside.

"Every household builds a garden, roads are swept and garbage is collected." Speaking of Fulin Village today, Zhao Fulong is like a few treasures. Since 2022, with the support of the Agricultural and Rural Committee of Qijiang District and the government of Dongxi Town, Fulin Village has invested 2 million yuan to upgrade the overall living environment of the village. After that, Fulin Village has changed its former appearance and its face value has improved significantly.

In order to continuously consolidate the improvement effect of human settlements and create a clean, tidy and orderly human settlements, Fulin Village regards the participation of human settlements and village-level public welfare undertakings as an important criterion for party member and the masses to evaluate the quality, and actively carries out the selection of "demonstration households of human settlements", "Hemei families", "civilized households" and "sanitary households" to fully mobilize the enthusiasm of the masses and form a good situation in which everyone participates in the improvement and maintenance of human settlements.

"Now not only is the village clean, but the villagers’ consciousness has also improved." Pu Degui, a 58-year-old villager, bought a house in Chongqing and wanted him to go to the city to enjoy himself. Feeling the changes in the village in the past two years, Pu Degui said frankly: "I don’t want to go to town. If you have nothing to do, you can get flowers at home, wait for the grass, or go out and have a look, which is particularly comfortable. "

"In the next step, we will firmly seize the opportunity of the construction of Fulin Reservoir, incorporate the ladder homestay, the Four Seasons Fruit Garden and the trail around the lake into the development plan of our village, and combine the characteristics of Fulin to create an recognizable brand of Fulin agricultural tourism, promote rural revitalization, and make the villagers feel more, happier and more secure." Zhao Fulong said. (Qin Ningbo, Wang Yu, Gu E)

Influenza has entered a period of high incidence, so don’t fall into these eight misunderstandings in the prevention and treatment of influenza!

  CCTV News:Every winter and spring is a high incidence of influenza. Recently, the National Influenza Center released the influenza surveillance report for the second week of 2019. The report shows that the level of influenza activity in the northern and southern provinces of China continues to rise, and it has reached the peak level of influenza epidemic. The flu is fierce, but some misunderstandings about the flu may be more terrible than the flu itself!

  Myth 1: This year’s flu is more serious than in previous years.

  Feng Zijian, deputy director of China CDC, said that the overall epidemic intensity of influenza this year is not as strong as last year, but it may be slightly stronger in some local areas. According to past experience, influenza may reach its peak in a week or two, and then the activity intensity of influenza will fall back.

  % of influenza-like cases reported by sentinel hospitals in southern provinces in 2015-2019 Source: National Influenza Center.

  According to the report released by the National Influenza Center, in the second week of 2019, the ILI% reported by sentinel hospitals in southern provinces was 5.5%, which was higher than the same period in 2016 and 2017 (3.2% and 3.1%) and lower than the same period in 2018 (6.0%); The ILI% reported by sentinel hospitals in northern provinces was 5.3%, which was higher than that in 2016 and 2017 (3.2% and 3.6%) and lower than that in 2018 (5.5%).

  Song Tie, deputy director of the Guangdong Provincial Center for Disease Control and Prevention, said that there were more outbreaks of influenza in primary schools this year, but with the school holidays, this outbreak will gradually decrease.

  Myth 2: This year, the emergence of "EB flu" and other variants of influenza virus is even more harmful.

  Recently, a message about the so-called "EB flu" circulated in the circle of friends, saying that "EB virus caused a severe flu", and the news that "the flu virus turned to attack children’s brains this year" also made many people fidget. Is there a mutation in this year’s influenza virus, and is it more harmful than before? Experts said that at present, the variation of influenza virus has not been found in various places, and there is no EB flu in medicine.

  Weibo screenshot

  According to experts, although there is EB virus, there is no EB flu. Symptoms such as fever and sore throat caused by EB virus have nothing to do with influenza, and EB virus itself is not highly pathogenic and contagious, so it generally does not need special treatment.

  Myth 3: Influenza is treated as a common cold.

  The symptoms of the common cold are mild, and most of them are respiratory symptoms such as sore throat, cough and stuffy nose. Generally, they will get better after seven to ten days. If there are complications, they are usually sinusitis and otitis media, and the consequences are not serious; The flu will be accompanied by high fever above 38℃, chills, dizziness, headache, muscle aches, etc., and it will also be complicated with severe pneumonia and myocarditis, which is sometimes fatal and highly contagious. Hundreds of thousands of people worldwide die of the flu every year. Experts suggest that once you have cold symptoms, you should go to the hospital in time to check and diagnose whether it is the flu or not, and prescribe the right medicine.

  Myth 4: taking drugs "just a few days"

  Experts pointed out that the antiviral drug oseltamivir can alleviate flu symptoms and reduce complications. However, oseltamivir has its timing: use it within 48 hours after suffering from influenza, and the earlier the effect, the better. If it exceeds the time limit, the effect will be ignored.

  Other cold medicines are only "symptomatic medicines" to relieve symptoms, and any cold symptoms can only be eliminated through the resistance of patients’ own immunity.

  Zheng Rongxiu, the chief physician of the General Hospital of Tianjin Medical University, pointed out that there are many anti-cold drugs now, which just make the symptoms of cold less and make people feel better, but have no effect on the course of the disease itself. After the course of the disease, most patients can recover with our immunity.

  Myth # 5: When you have the flu, the infusion will get better quickly.

  According to experts, glucose, saline, antibiotics or traditional Chinese medicine injections are generally infused, and none of them are necessary for treating influenza. Glucose and salt can be ingested from the diet, so as long as they can eat, there is no need to directly enter the vein. Influenza is caused by virus, and antibiotics are used to kill bacteria, which has no effect on virus infection and can’t prevent secondary bacterial infection. If you have a bacterial infection, you need to use antibiotics or take them orally. There is no need for infusion. As for traditional Chinese medicine injections, at present, the side effects are unknown and the infusion risk is high.

  No matter from the perspective of saving medical costs or safety, we should follow the principle that drugs can be taken orally without injection, and drugs can be injected without infusion.

  Myth # 6: Mixed use of multiple drugs is effective.

  Experts emphasize that taking a variety of cold medicines will not play much role in the curative effect, on the contrary, the risk of adverse reactions will be doubled.

  Xie Lixin, director of the Department of Respiratory Medicine, the First Medical Center of the PLA General Hospital, said that it is a three-point poison. In clinical work, the related side effects caused by drug abuse or excessive overdose are not uncommon, and the lessons are very profound.

  Myth 7: relying on "remedies" such as vinegar fumigation to prevent influenza

 

  In order to prevent the flu, some people smoke vinegar at home. Experts say that acetic acid can only kill bacteria when it reaches a certain concentration. Moreover, the flu virus is not a bacterium, and it cannot be killed by acetic acid at all. Blind vinegar fumigation will also aggravate the condition of patients with bronchitis and emphysema.

  Others rely on oral vitamin C to prevent influenza. Experts say that taking enough fruits and vegetables has the same effect as oral vitamin C, which can improve immunity, but it has no antiviral effect. According to the method of drinking Radix Isatidis and other traditional Chinese medicines to prevent influenza, experts said that Radix Isatidis is cool and not beneficial to all patients.

  Yang Shuyu, president of Xiamen Medical Association, Fujian Province, pointed out that it is very important to pay attention to improving one’s immunity when a cold is prevalent, and blindly taking drugs will affect and damage one’s immunity.

  Myth # 8: Strong people don’t have to be afraid of the flu.

  Experts say that people who are strong and have strong resistance should not think that their chances of getting the flu are low, so they don’t pay attention to rest and prevention, so that the virus also has the opportunity to take advantage of it, such as fatigue, hunger, or soaking clothes after sweating a lot. Among influenza complications, the incidence of myocarditis is higher in healthy young adults. This is because these people are more immune, and when they are invaded by the virus, their own defense system will also damage myocardial cells while removing the virus. 

  The prevention methods of influenza in active period have long been known.

  Do a good job in preventing influenza:

  1, keep indoor air circulation, pay attention to the clean environment;

  2. Maintain adequate sleep, healthy diet and moderate exercise;

  3. Pay attention to the weather change, add or subtract clothes with the temperature change to avoid catching cold;

  4. Pay attention to personal hygiene, change clothes and wash hands frequently, and cover your mouth and nose with paper towels or sleeves when sneezing or coughing.

  Children and the elderly should pay special attention to:

  1. Put an end to letting children attend classes with illness, try to avoid contact with patients with influenza-like cases, and wear masks if necessary;

  2. It is suggested that the elderly and residents with basic diseases should be vaccinated as soon as possible before the peak of influenza;

  3, the school nursery institutions should do a good job of absence monitoring due to illness and morning and afternoon inspection.

 

  Source: Weibo, Beijing Center for Disease Control and Prevention.

In 2023, the box office of China mainland movies broke 30 billion yuan.

  China News ServiceBeijing, July 14th (Reporter Gao Kai) According to the real-time data of Lighthouse Professional Edition, as of July 14th, the box office (including pre-sales) of China mainland movies in 2023 exceeded 30 billion yuan (RMB, the same below), which was close to the total box office of 30.067 billion yuan in 2022.

  According to the data of Lighthouse Professional Edition, up to now, the top five films at the box office in 2023 are: Man Jiang Hong (4.544 billion yuan), The Wandering Earth (4.029 billion yuan), Disappeared She (3.263 billion yuan), Bear with Me (1.495 billion yuan) and Octagon.

  In addition, Unfamiliar Road of Life, Speed and Passion 10, Unknown, Deep Sea and King of the Sky rank six to ten respectively.

  Since the Spring Festival this year, the domestic film market has shown a rapid recovery trend, and the box office performance of domestic films is particularly prominent. At present, among the top ten films at the box office, domestic films occupy nine of them and occupy the top five seats, which fully shows their dominant position in the cinemas in China.

  Since entering the summer file, domestic films such as Disappeared She, In an Octagonal Cage and Three Wan Li in Chang ‘an have continuously triggered a movie-watching craze here. The data shows that as of the 14th, the box office of this summer file has exceeded 7.8 billion yuan.

  On this basis, in late July, a number of films with box office appeal will be released soon, and the summer file is considered to be very likely to have further bright performance.

  Among them, the comedy "Super Family" produced by Mahua FunAge announced the final file on July 21. As of press time, the number of people who want to see the film in the lighthouse professional edition has exceeded 860,000; Directed by Dapeng and starring Bo Huang and YiBo, the drama "Enthusiasm" is scheduled for July 28th. At present, the number of people who want to see it has reached 610,000. In addition, the huge fantasy costume blockbuster "Feng Shen I" was finalized on July 20, which attracted people’s attention with its all-star cast, mysterious scenes and adaptation of the story of "Feng Shen Romance". At present, the number of people who want to see the index has reached nearly 470,000.

  The industry believes that the monthly box office in July 2023 is expected to break through the 7 billion yuan mark, creating a new box office record in the same month in China’s film history.

How to warn severe cases in COVID-19, and how to use hormones and antibiotics? Village doctors should master these points.

  The Spring Festival is approaching, and the population is flowing in large numbers, so the number of people who work in cities and return home to visit relatives for holidays will increase rapidly. This has also brought severe challenges to the treatment of rural COVID-19.

  "Grassroots medical and health institutions have undertaken a large number of tasks of first diagnosis of patients and classified management of key populations." On January 14th, Nie Chunlei, director of the Department of Primary Health and Health in National Health Commission, said that there was an imbalance in medical resources between urban and rural areas, with obvious differences, and health service resources in rural areas were relatively insufficient. "Grassroots village doctors urgently need to master the knowledge and skills of Covid-19 infection diagnosis, severe early warning and treatment, especially the use of antibiotics, hormones and small molecule drugs, so that patients can be effectively treated."

  On January 11th, the General Practice Branch of Chinese Medical Association, together with several branches, issued the "Guidelines for Diagnosis, Treatment and Service of Infections in novel coronavirus (First Edition)" (hereinafter referred to as the "Guidelines"), which elaborated on diagnosis, clinical classification, identification, treatment and treatment of severe cases.

  How to warn of moderate and severe diseases?

  "For the grassroots, the evaluation of COVID-19’s diagnosis and clinical typing is more important, and it is also the whole of the diagnosis and treatment strategy." Wu Hao, the correspondent of the Guide and dean of the School of General Practice and Continuing Education of Capital Medical University, said.

  In the evaluation of patients’ clinical typing, Wu Hao said that the majority of grassroots village doctors need to pay special attention, and the evaluation of vital signs can be carried out through a simple "four-piece set" of body temperature, respiration, heart rate and blood pressure; In the measurement of finger oxygen saturation, due to the low outdoor temperature in winter, the village doctor found that the patient’s limbs or skin were cold, and its oxygen saturation value may be less than 93%, but this does not mean that the patient is at risk, and it is necessary to judge by observing whether the lips are purple and dry.

  Imaging examination can be based on chest X-ray or CT. If there is pneumonia in COVID-19, most of it occurs in the lower lungs. If there is no CT in rural medical institutions, you can auscultate whether the patient’s lower lungs are accompanied by wet rales (if there is, CT examination is not necessary); Instead of taking X-ray chest film, you need to pay attention to the patient’s posterior and anterior and lateral films, and sometimes you can see some exudative and inflammatory lesions. Although the X-ray chest film may miss the diagnosis, if the chest film shows pneumonia, the actual situation of the patient will be more serious.

  "What needs to be repeatedly emphasized is the early warning of severe illness." Wu Hao said that the patient’s three situations indicate that it is very dangerous and may progress to severe illness. First, moderate and severe dyspnea occurred, including (meeting one of the following conditions) heart rate greater than 120 beats/min, breathing frequency greater than 30 beats/min, and breathing with an auxiliary ventilator (pay attention if the patient cannot speak a whole sentence during the consultation); Second, the oxygen saturation is lower than 93%; In addition, if the patient has chest pain, falls, changes of consciousness, low blood pressure, decreased urine output, severe vomiting or diarrhea, etc., we should also consider severe warning.

  Zhang Wenhong, director of the Department of Infectious Diseases of Huashan Hospital affiliated to Fudan University, said during the training that after the implementation of the "Class B and Class B Management" policy, it is crucial for grassroots doctors to master the transformation from Chinese diseases to severe diseases in the process of normalizing COVID-19 treatment. In particular, the clinical classification of patients was adjusted in the "novel coronavirus Infection Diagnosis and Treatment Program (Trial Tenth Edition)", instead of ordinary type, it was medium. "Light and medium-sized should be treated at the grassroots level. Therefore, the grassroots should prevent medium-sized to heavy-duty, and heavy patients need to be referred in time. "

  Zhang Wenhong said that in the clinical early warning of severe illness, one indicator has changed and it is necessary to be alert to the deterioration of the patient’s condition, that is, the patient is "hypoxic after activity; After slight activity, the oxygen saturation value is less than 94%, which can make the patient walk back and forth in the corridor. If his CRP(C-reactive protein), lactic acid and other indicators are normal, it means that the oxygen saturation value has decreased, which is also a signal of the progress of the disease.

  How to use hormones and antibiotics?

  Is it really effective for rural doctors to use the four-piece set of "antiviral+antibiotic+hormone+antipyretic"?

  Wu Hao explained that, in fact, the elderly people in rural areas were not treated in time after onset, and there was malnutrition. When he went to the clinic for medical treatment, he might be in the acute pneumonia period, and even had a bacterial infection. At this time, the village doctor will give hormone and antibiotic treatment, and the effect will be more obvious.

  Regarding whether antiviral drugs can be used for more than 7 days, Wu Hao said that the time of viremia is usually 7 days. The reason why antiviral drugs are prescribed to be used within 5 days of onset is because the earlier they are used, the greater the benefit, which also takes into account the incubation period of 1 ~ 2 days. "For the elderly and frail patients, the process of virus clearance is slow. At this time, even if the illness lasts for more than 7 days, it will still be effective to continue using antiviral drugs."

  Wu Hao further said that the use of antibiotics should also avoid blindness and should be judged with reference to the patient’s indications. For example, if the patient coughs dry or coughs white sputum, or has less sputum in the early stage, this is a viral infection; If the patient has pus or coughs yellow sputum, it is generally a bacterial infection. If the village doctor doesn’t have the above-mentioned accurate detection means, he can write it all in combination with the patient’s situation, that is, his family members are infected and have flu symptoms, and he also has lung symptoms, which is definitely viral pneumonia, but if his family members don’t have it, it is the possibility of community-acquired pneumonia.

  In order to facilitate the operation of primary doctors, the "Simplified Edition" published on January 4th referred to the "four-step" treatment of COVID-19 at the primary level: general treatment, oral small molecular antiviral drugs, glucocorticoid, oxygen therapy and respiratory support.

  Therefore, Zhang Wenhong emphasized that glucocorticoid should be used with great caution. It is suitable for COVID-19 patients with high-risk factors (older, with medium-sized clinical manifestations and evidence of disease progression). At this time, low-dose and short-term corticosteroids can be given. "Specific usage, you can use dexamethasone or prednisone, 4 ~ 6 tablets a day, eat for 3 days. Within 72 hours, the patient will face a turning point. If the patient gets better quickly, it will be reduced to 2-3 tablets and taken for another 3 days. If it is relieved later, either stop taking the medicine or use another tablet for 3-4 days. If the patient progresses to severe illness, he needs to be hospitalized for observation, and the dosage of hormones can also be increased, and the treatment plan for severe patients can be started later. "

  "On the one hand, an early British clinical study showed that the daily use of 6 mg dexamethasone in large-scale hospitalized patients in COVID-19 can reduce the mortality rate; On the other hand, our team also gives patients low doses of hormones in the early stage of severe illness, which can greatly reduce the intubation rate of patients and reduce the mortality rate. " Zhang Wenhong said.

  The Guide stipulates that glucocorticoid can be used for patients with early onset in the community, such as high-risk factors such as basic diseases and advanced age, or medium-sized patients who need oxygen therapy, after evaluating the contraindications of hormone use.

  Zhang Wenhong said that "prone position ventilation treatment" for COVID-19 patients can be operated regardless of the resources of rural medical institutions, and it is suitable for medium-sized patients with severe high-risk factors and rapid progress. This is also recommended by many respiratory and critical care experts.

  "When the patient is lying on his back, the heart and lungs are under certain pressure, and there will be problems in the proportion of ventilation blood flow. After prone, the pressure on the heart and lungs is reduced, the proportion of ventilation blood flow will be more balanced, and the physiological diseases related to inflammation of patients will also get better. " Li Yingchuan, an expert in critical care medicine and vice president of Shanghai Tenth People’s Hospital, explained to reporters earlier.

How difficult is it for Legal Companion to travel to London to interpret overseas shooting exclusively?


Special feature of 1905 film network On March 12th, the light comedy of love was released in China. The film focuses on the difficulties encountered by China students when they drifted to Britain. In order to make up for the unexpected mistake that Gu Dabai was about to be deported because he failed to renew his contract in time, Jin Tian, a good brother, came up with a "good idea" to hide the truth and keep Gu Dabai.


The story took place in England, and the audience also followed the movie on a cloud tour. In addition to St. Paul’s Cathedral, Thames, London Eye and other famous attractions, the scenery of unknown blocks is also a major attraction of the film. These blocks have a British texture, showing the real "London style".



In this issue, I specially invited the director of Legal Companion to share with us his film shooting strategy in Britain."The preparatory period for the film" Legal Companion "to shoot in the UK has been almost one year, because we have to look at the scenery first, and then we have to declare this permission to the British government quickly. Only when we get the permission can we really shoot."



"Basically, if you want to finish this film, you have to follow the previous production plan and finish what you planned to finish at every fixed time, because Britain is a country that pays great attention to commitments and contracts. All the forms we fill in and the applications we submit are official commitments, so we have given people this commitment, and we must complete this work within this commitment. "



At the beginning of the film, Gu Dabai rode through the block. In fact, this seemingly ordinary living shooting location also needs to be fully prepared.


"With the understanding of the domestic audience, the traditional filing in our country is different. Britain is a country with private ownership, and its land is allowed to be privately held. Therefore, when I shoot in one street, it is very likely that I will shoot three streets together. The former street belongs to the government and the third street belongs to an individual. After I submit the report to the government, I have to get his permission from the owner of the individual before I can get the whole scene. "


In addition to the beautiful scenery in the film, the casting and dressing of the film are also very British. The leading actor with a mixed-race face studied in Britain during his undergraduate period and lived in the same semi-basement house as in the film. "Semi-underground is a place to live that particularly reflects the identity of international students." We can also get a glimpse of the real life of "Ying Piao" in the movie by renting the basement in the wet England.



In recent years, it is not uncommon for China films to be filmed in foreign countries. The film released in this year’s Spring Festival not long ago also encountered many production problems when shooting in Japan. When shooting in a busy street, the crew must go through the consent of every store and every business before shooting in this street, and they must apologize to the residents and passers-by who are disturbed by it.



Cultural differences in different countries and different modes of film industry production have brought various difficulties to China films with transnational cooperation. To overcome these difficulties, what we have to do is to know the local culture in advance and do our homework well. Respecting and being honest with each other is the essence of making a good transnational cooperative film. Director Huang Lei bluntly said: "You must give the other party enough respect before the other party will give you respect and allow you to shoot."



Transnational cooperation in China movies can not only bring viewers the viewing experience of cloud tourism in different regions, but also bring different cultural environment cores to the story of the movie itself. In order to avoid the story and the beautiful scenery, we must have a deep understanding of the location of the story, and whether the location can fit the regional and cultural background of the story is also the direction that filmmakers need to pay attention to in transnational cooperative films.


"The style of the whole British society is not only focused on the beautiful scenery, but also has more British people, British life, British social things, and some bits and pieces of details, so these details constitute the whole overseas culture. It is particularly realistic to let our characters live in such an environment."



Legal Companion can successfully bring the audience the real life state of young people overseas, which is inseparable from the early understanding of British regional culture. The cross-border cooperative shooting strategy shared by director Huang Lei also gives filmmakers, especially young directors who want to shoot similar themes, some experiences that can be used for reference. "I think it is still necessary to understand the people in this place, their daily thinking habits and living habits, and then what will happen when different cultures collide."



Nowadays, China movies with transnational cooperation emerge one after another. While putting an exotic coat on the environment, we hope that the movies can tell the stories of people in different cultural backgrounds at the same time. Now we have a series of successful examples, such as "Legal Companion", and we are looking forward to more and more such films.



The director’s observation of today’s film review;Many people may think that shooting abroad is a special pleasure, but it is endless pressure for directors. Shooting abroad means higher costs, and the accommodation and travel of the whole crew will become a big account. Shooting abroad may also face more unknowns and risks, and the director needs to make a quick decision in a limited time and finish shooting efficiently. Because I watched the director’s special film in Japan, I feel confident like him, and sometimes I hesitate and make trouble, which is even more challenging for the new director. (Wu Zhiying)


He changed from an air conditioner installer to a business owner.

Liu Xianbao at Work

Liu Xianbao at Work

CCTV News:21 years ago, Liu Xianbao graduated from high school. At that time, his sister was not married, his brother was unemployed at home, and his old father worked hard to keep the house alone. In order to reduce the burden on his family, Liu Xianbao came to Shanghai alone from his hometown of Wuhu, Anhui Province and became an air conditioner installer.

When he first arrived in Shanghai, Liu Xianbao rode his bicycle to install air conditioners in every house before dawn every day, and worked 15 hours a day. A year later, he realized that it is difficult to get any big gains by working hard, and only by learning excellent technology can he break into a brand-new world.

As a result, Liu Xianbao began to spend most of his savings on his studies. After work, he finds time to participate in various skills training. In 1998, Liu Xianbao was admitted to an air-conditioning company, and he jumped from a junior maintenance worker to a senior technical backbone within one year. He also accepted four apprentices as an excellent old teacher.

However, Liu Xianbao always holds such an idea in his heart: to be his own brand, run his own company and do something.

In 2002, with rich work experience, Liu Xianbao opened his own maintenance shop. Unlike ordinary repair shops, Liu Xianbao’s shop is not in the bustling street, but is wrapped in the depths of the grocery market by clothing shops and daily necessities shops. Repairing electrical appliances is generally a regular business, and it is the primary task to let residents know and convey their sincerity actively. In addition to excellent maintenance technology, retaining customers depends on a business philosophy different from others. Liu Xianbao made such a sign: free of service charge and only charge for materials.

As a result, the store’s signboard became a hit, and residents in the community took out recorders, radios and remote controls that had been in disrepair for a long time to come to Liu Xianbao for maintenance. For the elderly over 80 years old, he took the initiative to come to help repair. Because the maintenance is all small household appliances, we have not earned any money, but also posted a lot of money.

Although I lost money, I won word of mouth. Liu Xianbao’s maintenance department is getting bigger and bigger, and his public service is getting bigger and bigger.

one

Liu Xianbao (middle)

In May 2008, Liu Xianbao set up the "Spring Care" service team to help the elderly, and carried out free air-conditioning cleaning and maintenance services for elderly people and disabled families living alone in the community. As long as a phone call is made, Liu Xianbao will immediately dispatch a special person to the door for maintenance. All small household appliances are free, and everyone only charges material fees. Over the years, he has benefited hundreds of thousands of yuan and repaired more than 100,000 home appliances.

Taking care of each other is naturally the concern of the residents. In the hot summer, some residents will send Liu Xianbao an iced drink to quench thirst and dispel summer heat. In the cold winter, some residents will come and give Liu Xianbao a cup of hot water and a greeting.

Now, 43-year-old Liu Xianbao has his own company.Sub-centers have been opened in 11 towns and industrial parks in Minhang District, Shanghai, covering more than 600 communities, and public welfare services have naturally not fallen behind. He rebuilt the old family lines for the solitary, pure old and lonely old families in Jiangchuan Street, and opened the safety files of electricity and gas consumption for the elderly over 60 years old, so as to reduce the risk of fire and gas poisoning in residents’ families.With this love, he found a new neighborhood friendship, a lifelong career and a home for his soul in this city.

"When I was studying, I saw a lot of Shaw House on campus. Later, I learned that these were donated by Mr. Run Run Shaw, who has done a lot for public welfare. I want to be like him. This is my ideal. " Liu Xianbao said. (Source: CCTV Network)

Golden Globe Award Prediction: Boyhood has the highest chance of winning in 12 years.

    Special feature of 1905 film network Judging from the whole nomination situation, the Golden Globe Awards still follow the old way of "summarizer" in the award season. Still those familiar faces, or those familiar films, or a large and comprehensive nomination list. According to the trend of films in the award season, the number of awards won and the word-of-mouth of film critics, on the whole, and followed closely, while, and these three biographies are too safe and mainstream, and basically lose the chance to win the first prize. The alternative inspirational films, which have been popular since last year, are a little weak. Although the director Damien Chazelle became famous, he probably can’t do much.

 

    There are 30 nominations for the performance category of the Golden Globe Awards, which is somewhat "chaotic". However, there are only a few popular actors who have the chance to win the prize. The situation of actor melee is more complicated. Everyone has the opportunity and strength. Among the actresses, Julianne Moore was shortlisted for two best actress awards with Starway, which is the candidate with the highest chance.

 

Best drama: 4/5 is the biography "Youth" still has the highest chance of winning.

 

    Of the five films nominated for best drama, four are biographies. Selma tells a story about Martin Luther King, while The Imitation Game focuses on the legendary Turing. The protagonist of The Theory of Everything is Hawking. It is worth mentioning that after watching this movie, Hawking made it clear that he likes this movie very much, and although it was spit out by the prototype of the characters, as a movie, it is complete and full of emotions. Although it has a certain style tendency, it is somewhat far from ordinary fans, but it takes a lot of advantage in the award selection.

 

    Among the five films, the only fictional film — — "Youth" is the most like a documentary. In pursuit of authenticity, film director richard linklater spent 12 years shooting this film. Waiting for the actor to grow up abruptly, filming the growth and change of an American youth from 6 to 18 years old. You can say that this is the director’s paranoia and his willfulness — — Of course, on the artistic level, this is the embodiment of a director’s ethics and execution.

 

    According to the mainstream media in North America, "Youth" is unparalleled, not only because of the 12-year shooting time, but also because of the calm and indifferent texture conveyed in the film. In contrast, The Imitation Game is somewhat commercialized, while The Theory of Everything is like a love fairy tale, without the heavy feeling of winning the prize. Although The Fox Catcher is powerful, its restrained lens language and criticism of wealth still make the film not within the scope of mainstream values. Moreover, in recent days, the film has been "hated" by the protagonist prototype on social networking sites for seven times in a row, which is at the forefront of public opinion. Selma’s large-scale release time is very short, and its influence is limited. Moreover, it has already talked about racial issues last year, and the film theme is not dominant. Therefore, in terms of the best drama, "Youth" has the greatest chance of winning.

 

Best Music/Comedy: Birdman or Beating The Grand Budapest Hotel.

 

    A small mix of geek comedies, gay movies and fairy tales is the second-tier film among the five nominated films in this award. First of all, the word-of-mouth of "Magic Black Forest" is quite general, and some media even think that the whole film is nothing except Meryl Streep’s performance. The remaining two films, although of acceptable standard, are indeed dispensable films in the award season. Apart from the Golden Globe Award, which lists comedy/music films separately, these two films are hard to find in the awards season. The remaining two films, Birdman and The Grand Budapest Hotel, are popular films in the award season. Moreover, the unique and unforgettable Birdman is very promising in the Oscar selection.

 

    The Grand Budapest Hotel has a strong wes anderson style and is a unique work of this unique director. However, Anderson’s performance at the Golden Globe Award is very ordinary. This is his first nomination for the Golden Globe Award, and the chances of winning the award are not great, because those who were nominated for the Oscar before, and, all lost their trophies at the Golden Globe Award. Therefore, this "same recipe, same taste" film is hard to win at the Golden Globe Awards. Therefore, Bird Man, which is technically impeccable and has a strong "fantasy" plot, has become the film with the highest winning rate. Moreover, in this film, alejandro gonzalez inarritu also teased Hollywood by accident, showing his views on Hollywood as a Mexican "outsider". His view may win the favor of the Golden Globe Award hosted by hollywood foreign press association.


Best director: Richard Linkte’s 12-year sword-sharpening award is in sight.

 

    There are only five nominated best director awards, which are the most variable and the most competitive. Linklater, the director of "Youth", used time, patience, emotion and execution to make a fictional film show the reality of documentary. The film thus gained an incredible texture. Although the three-hour-long film is a little dull and boring, it is as memorable as the taste of life. Especially the mother in the film, she said that after sending her two children away, she was waiting for her funeral, which was quite touching.

 

    Birdman is full of whimsy. Although the clues of the story are old-fashioned, Inarito took the story to another level with his own means and skills of "turning ordinary into extraordinary". Although female directors ava duvernay, who filmed Selma, is 42 years old, she can be said to be a new director. Her outbreak this year has something to do with her accumulation in the circle for nearly ten years. Moreover, the black perspective and the film mixed with black street elements are refreshing.

 

     As for wes anderson and david fincher, they just contributed the films engraved with their style as always, without any breakthrough or innovation. This kind of directing work, at best, is called personal style; At worst, it is called standing still and standing still. Therefore, these two are not very competitive in the best director award. On the whole, richard linklater’s epic shooting process and extraordinary creativity are likely to win him the honor of best director.

next page Performance awards: michael keaton and Julianne Moore have obvious advantages.